Management of childhood cerebellar astrocytoma.

International Journal of Radiation OncologyBiologyPhysics (Impact Factor: 4.18). 05/1990; 18(4):971-3. DOI: 10.1016/0360-3016(90)90425-J
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    ABSTRACT: Advances in genetics and neuroimaging have revolutionized the diagnosis of intracranial disease in children. An integrated approach to these diseases has also emerged from the proliferation of multidisciplinary clinics and programs combining expertise in pediatric neurology, neurosurgery, neuropathology, neuroradiology, neuro-oncology, and neuro-ophthalmology. The role of genetic defects is increasingly recognized in many intracranial disorders, and basic research elucidates their pathogenesis at the molecular level. Refinement in neurosurgical management continues to advance the treatment of these disorders, while preventative and therapeutic measures will arise from molecular genetic research.
    03/2010: pages 503-596;
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    Management of CNS Tumors, 09/2011; , ISBN: 978-953-307-646-1
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    ABSTRACT: Background. The majority of patients with astrocytomas of the cerebellum have an excellent prognosis; however, a small percentage of patients continue to do poorly. To clarify the clinical, pathologic, and treatment characteristics that determine prognosis and therapeutic recommendations, a large group of patients with astrocytic tumors of the cerebellum was reviewed and analyzed.Methods. A clinicopathologic analysis was performed of all patients undergoing initial operation for astrocytomas in the cerebellum between 1960 and 1984. Of the 132 patients, 105 patients had pilocytic astrocytomas and 27 had diffuse astrocytomas.Results. Multivariate analysis revealed that the division of pilocytic and diffuse histologic type was the most significant prognostic factor influencing survival. The 5-year, 10-year, and 20-year survival rates were 85%, 81%, and 79%, respectively, for patients with pilocytic astrocytomas and 7%, 7%, and 7%, respectively, for patients with diffuse astrocytomas (P < 0.001). Pilocytic astrocytomas occurred in a younger age group and were more commonly cystic and completely resected.Conclusions. Astrocytomas of the cerebellum can be divided into two principal groups, the pilocytic and the diffuse astrocytomas, each of which has distinct clinical, pathologic, and prognostic characteristics.
    Cancer 08/1993; 72(3):856 - 869. DOI:10.1002/1097-0142(19930801)72:3<856::AID-CNCR2820720335>3.0.CO;2-K · 4.90 Impact Factor