HLA typing in actinic prurigo

Department of Medicine, University of Saskatchewan, Saskatoon, Canada.
Journal of the American Academy of Dermatology (Impact Factor: 5). 07/1990; 22(6 Pt 1):1019-23. DOI: 10.1016/0190-9622(90)70144-7
Source: PubMed

ABSTRACT Thirty-two actinic prurigo patients of Cree ancestry underwent human lymphocyte antigen (HLA) typing and were compared with 32 control subjects of Cree ancestry. We found a significantly increased frequency of HLA-A24 and Cw4 antigens and a significant decrease in the frequency of the A3 antigen in actinic prurigo patients. These HLA associations may be helpful in determining whether actinic prurigo is a distinct disease or a variant of polymorphous light eruption.

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