HLA typing in actinic prurigo
ABSTRACT Thirty-two actinic prurigo patients of Cree ancestry underwent human lymphocyte antigen (HLA) typing and were compared with 32 control subjects of Cree ancestry. We found a significantly increased frequency of HLA-A24 and Cw4 antigens and a significant decrease in the frequency of the A3 antigen in actinic prurigo patients. These HLA associations may be helpful in determining whether actinic prurigo is a distinct disease or a variant of polymorphous light eruption.
Article: Actinic Prurigo.[Show abstract] [Hide abstract]
ABSTRACT: Actinic prurigo is a chronic photodermatosis with onset in childhood or before 20 years of age. It is most prevalent in Amerindians and Latin American mestizos, although it has been reported worldwide. Patients present with photodistributed, erythematous excoriated papules, cheilitis, and conjunctivitis. There is strong association with human leukocyte antigen DR4, especially the DRB1*0407 subtype. Treatment consists of photoprotection and the use of thalidomide.Dermatologic Clinics 07/2014; 32(3):335-344. DOI:10.1016/j.det.2014.03.010 · 1.43 Impact Factor
Article: Photosensitivity diseasesJournal of the American Academy of Dermatology 09/1982; 7(3):424. DOI:10.1016/S0190-9622(82)80332-0 · 5.00 Impact Factor
Article: Actinic PrurigoInternational journal of dermatology 02/1994; 33(2). DOI:10.1111/j.1365-4362.1994.tb01550.x · 1.23 Impact Factor