Gastric emptying in patients with fundal gastritis and gastric cancer.

Department of Gastrointestinal Oncology, Centre for Adult Diseases, Osaka, Japan.
Gut (Impact Factor: 10.73). 08/1990; 31(7):767-9. DOI: 10.1136/gut.31.7.767
Source: PubMed

ABSTRACT Gastric emptying was compared in patients with gastric cancers and fundal gastritis to determine its value in identifying patients at high risk of gastric cancer. Gastric emptying was measured by the acetaminophen absorption method, and the extent of fundal gastritis was determined by the endoscopic Congo red test. The results showed that gastric emptying was significantly slower in patients with severe fundal gastritis than in those without. Gastric emptying in patients with differentiated adenocarcinomas was significantly slower than in those with undifferentiated adenocarcinoma, its value being similar to that in patients with severe fundal gastritis. The Congo red test showed that the incidence of severe fundal gastritis was significantly greater in patients with differentiated adenocarcinomas than in those with undifferentiated cancers. These findings suggest that delayed gastric emptying may allow prolonged contact between dietary carcinogens and the stomach.

  • Scandinavian Journal of Gastroenterology 11/1995; 30(10):929-34. · 2.33 Impact Factor
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    ABSTRACT: To investigate whether the sulfamethizole absorption test can be applied for the assessment of gastric emptying, we measured comparatively plasma sulfamethizole concentration and gastric emptying as determined by scintigraphy in 15 subjects. After the ingestion of a solid-liquid meal that contained sulfamethizole and radioisotope (technetium-99m-labeled diethylenetriaminepentaacetic acid), the plasma sulfamethizole concentrations were measured every 15 to 60 min up to 180 min. The initial emptying time (duration after ingestion until 10% reduction in radioactivity of the stomach) and the exponential curve in the cumulative reduction of radioactivity were used as indicators of gastric emptying. The initial emptying time was significantly correlated with the sulfamethizole concentration at 15 min after ingestion (r = -0.64, p < 0.05). A close correlation was observed between the rate of decrease in radioactivity and sulfamethizole concentration at 60 min after ingestion (r = 0.80, p < 0.001). The sulfamethizole absorption test can be used for the evaluation of gastric motility. Two points of measurement, 15 and 60 min after ingestion, are sufficient to demonstrate the initial and subsequent gastric emptying.
    Scandinavian Journal of Gastroenterology 03/1995; 30(2):133-8. · 2.33 Impact Factor
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    ABSTRACT: Using a homemade electrogastrography (EGG) system, we studied the characteristics of myoelectrical rhythm in gastric cancer (GC) patients. Based on a short-term Fourier transform, recorded slow waves could be automatically analyzed to obtain the following parameters: dominant frequency/power, percent of normal rhythm (2.4–3.7 cpm), power ratio, etc. Fifty histologically confirmed GC patients (34 men, 16 women) were enrolled before surgical intervention to measure their fasting and postprandial EGG parameters for 30 min. The cancerous parameters of GC patients were then obtained postoperatively. In addition, 46 healthy subjects were enrolled for comparison. When compared to controls, GC patients had the following characteristics: absence of postprandial increase in dominant frequency (GC: 3.04 0.47 vs 3.07 0.44 cpm, NS; controls: 3.02 0.31 vs 3.21 0.25 cpm, P < 0.001),="" marked="" power="" response="" after="" meal="" (p="">< 0.05),="" and="" obvious="" power="" ratio="" (4.58="" ="" 7.38="" vs="" 2.27="" ="" 2.05,="" p="">< 0.05).="" multivariate="" analysis="" indicated="" that="" advanced="" gc="" was="" the="" factor="" responsible="" for="" the="" obvious="" dominant="" power="" enhancement="" after="" meal="" (p="">< 0.05).="" other="" demographic,="" clinical,="" and="" cancerous="" factors="" did="" not="" influence="" egg="" parameters.="" we="" conclude="" that="" apparent="" arrhythmia="" is="" not="" encountered="" in="" gc="" patients,="" although="" they="" mainly="" exhibit="" obvious="" postprandial="" power="" response.="" advanced="" gc="" is="" likely="" responsible="" for="" this="" power="" enhancement="" on="" egg="">
    Digestive Diseases and Sciences 06/2001; 46(7):1458-1465. · 2.26 Impact Factor


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