Clinical experience with a new artificial bone graft: preliminary results of a prospective study.
ABSTRACT This prospective study was carried out to determine the efficacy, benefits and safety of an artificial bone grafting material. The material used was a mixture of porous calcium phosphate ceramic with the addition of bovine fibrillar collagen and autogenous bone marrow. This mixture has been used successfully as a bone graft in 11 patients with delayed and non-union of long bones.
Chapter: Fabrication of Bio-Nanocomposite Nanofibers Mimicking the Mineralized Hard Tissues via Electrospinning Process[show abstract] [hide abstract]
ABSTRACT: In the present work we demonstrate a powerful technique for fabricating biocompatible and biodegradable PVA/HAp nanocomposite fibers in order to mimic mineralized hard tissues for bone regeneration purpose by applying the electro spinning process. Various techniques, including TEM, HR-TEM, SEM, XRD, DSC, TGA, FTIR spectroscopy were performed to characterize the resulting electrospun PVA/HAp composite nanofibers in comparison with pure PVA and PVA/HAp nanocomposites before electrospinning. Morphological investigation showed that the HAp nanoparticles exhibit nanoporous morphology, which provides enlarged interfaces being a prerequisite for physiological and biological responses and remodeling to integrate with the surrounding native tissue. The most striking physiochemical feature of the electrospun PVA/HAp composite nanofibers is that the HAp nanorods are preferentially oriented parallel to the longitudinal direction of the electrospun PVA fibers as confirmed by electron microscopy and XRD. This feature bears strong resemblance to the nanostructure of mineralized hard tissues serving as building block of bone. Furthermore, the PVA as matrix and HAp nanorods as inorganic phases strongly interact through hydrogen bonds within the electrospun PVA/HAp nanocomposite fibers. The strong bonding due to the presence of a great extent of OH groups in the PVA polymer and the HAp nanorods leads improved thermal properties. The hybrid electrospinning shown in the present work provides great potential as a convenient and straightforward technique for the fabrication of biomimicked mineralized hard tissues suitable for bone and dentin replacement and regeneration. However, a great challenge still exists mainly in how to stabilize the electrospun PVA/Hap nanofibers when in contact with an aqueous medium. Such deficiency could be resolved by proper chemical and/or physical treatments of the material that are currently under investigation.02/2010; , ISBN: 978-953-7619-86-2