Article

Expression of c-fos and c-myc proto-oncogenes in human adrenal pheochromocytomas.

Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Journal of Clinical Endocrinology &amp Metabolism (impact factor: 6.5). 03/1990; 70(2):353-7.
Source: PubMed

ABSTRACT We examined c-fos and c-myc expressions in pheochromocytoma tissues from six patients. All samples contained c-fos and c-myc transcripts, whereas mRNA from bovine adrenal medulla, as a control, did not contain these transcripts at detectable levels. Southern blot analysis revealed no amplification and no rearrangement of c-fos and c-myc genes. We also examined the gene expression of insulin-like growth factor-II (IGF-II), a mitogen for rat pheochromocytoma cells exerted by autocrine or paracrine fashion. All samples from the pheochromocytomas contained IGF-II transcripts as well as c-fos and c-myc transcripts. The constitutive expressions of c-fos and c-myc genes may be interpreted to mean that pheochromocytoma is in a state of growth stimulation in vivo by growth factors, including IGF-II.

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Keywords

amplification
 
autocrine
 
bovine adrenal medulla
 
c-fos
 
c-myc expressions
 
c-myc genes
 
c-myc transcripts
 
constitutive expressions
 
detectable levels
 
gene expression
 
growth factors
 
growth stimulation
 
IGF-II transcripts
 
insulin-like growth factor-II
 
mitogen
 
patients
 
pheochromocytomas
 
rat pheochromocytoma cells
 
Southern blot analysis
 
transcripts
 

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