Article

Florid mesonephric hyperplasia of the cervix: a report of a case with review of the literature.

International Journal of Gynecological Pathology (Impact Factor: 1.41). 02/1985; 4(3):245-54. DOI: 10.1097/00004347-198509000-00009
Source: PubMed

ABSTRACT A rare case of florid mesonephric hyperplasia (FMH) of the cervix found incidentally in the hysterectomy specimen of a 49-year-old woman was studied with light and electron microscopy as well as histochemistry and immunohistochemistry. A lack of architectural and cytologic atypia of the glands and tubules and a benign clinical course are consistent with a hyperplastic rather than neoplastic process. Direct histologic continuity between mesonephric duct remnants and hyperplastic glands with numerous cytotelolysosomes and lack of intracellular mucin and carcinoembryonic antigen are the features that distinguish FMH from minimal deviation adenocarcinoma of the endocervix.

0 Bookmarks
 · 
109 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: A case of carclnosarcoma of mesonephric origin in a 58 year old woman Is reported. A cystic tumor with a solid area, measuring 14 cm in greatest diameter, was detected in the pelvic cavity by computerized tomography and ultrasound. Although it was diagnosed as an ovarian cancer for surgical removal, it was found to be entirely located in the myomet-rium of the left lateral wall of the uterine body and neither ovary was remarkable. Histologically the tumor was composed of epithelial and sarcomatous components. The former showed low papillary pattern, crowded solid nests and cords of cells, and focal tubular structures. The latter showed a solid growth pattern with differentiation to leiomyo-sarcoma. In the uterine cervix, a 1.2 cm mesonephric (Gartner's) cyst was found. Neither neoplastic lesions nor endometriosis were identified in the cervix, endometrium, fallopian tubes or ovaries. Based on the histologic features and the specific location of the tumor, the coexistence of Gartner's cyst, and the normal appearance of the endocervi-cal mucosa as well as the endometrium, it was diagnosed as a mesonephric carcinosarcoma. The serum levels of carci-noembryonic antigen, CA125, CA19–9, and CA72–4 were within normal ranges in the clinical course. The patient died of disease 8 months after surgery.
    Pathology International 12/2008; 45(4):303 - 309. · 1.72 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: A very rare case of mesonephric adenocarcinoma with lobular mesonephric hyperplasia in the uterine cervix of a 46-year-old female is presented. The lesion was a 4 cm, exophytic, almost circumferential, whitish yellow, friable mass in the uterine cervix. Microscopically, the tumor was composed predominantly of atypical round to polygonal cells arranged in a ductal, tubular, or papillary pattern. The tumor involved the entire cervix with varying depths of penetration. Lobular mesonephric hyperplasia was also observed in the lateral cervical wall and adjacent to the tumor. Immunohistochemically, the tumor was positive for CAM5.2, CK7, epithelial membrane antigen, calretinin, and chromogranin A, and was negative for vimentin, carcinoembryonic antigen, estrogen and progesterone receptors, and CD10. An ultrastructural analysis showed telolysomes, which were characteristic features of mesonephric epithelium. The patient was alive without disease at 4 months after surgery.
    Pathology - Research and Practice 04/2008; 204(9):671-6. · 1.21 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Two cases of mesonephric duct hyperplasia of the uterus, together with three cases of uterine mesonephric duct remnant, are reported. The latter cases were identified by serial transverse sectioning of 42 surgically resected uteri, yielding a frequency of approximately 7%. Histochemical studies showed no mucin in the cytoplasm of cells lining the mesonephric duct remnant, as well as mesonephric duct hyperplasia. In contrast, the endocervical epithelium had abundant neutral mucin, sialomucin and sulfomucin. Im-munohistochemical studies on lectin binding showed positive binding of PNA and SBA lectins only to the lining cells of mesonephric duct hyperplasia. Acta Pathol Jpn 39: 457 464, 1989.
    Pathology International 12/2008; 39(7):457 - 464. · 1.72 Impact Factor