“Neat reaction technology for the synthesis of 4-oxo-thiazolidines derived from 2-SH benzothiazole and antimicrobial screening of some synthesized 4-thiazolidinones”

Journal of the Iranian Chemical Society (Impact Factor: 1.41). 09/2006; 3 (3):233-241. DOI: 10.1007/BF03247213

ABSTRACT The synthesis of 4-thiazolidinones 4a-j in a good yields from the heterocyclization reaction of 2-(benzothiazol-2-ylthio)-N’-benzylideneacetohydrazide 3a-j with SHCH2COOH in DMF in the presence of a catalytic amount of anhydrous ZnCl2 under microwave irradiation is described and compared with conventional synthesis methods. All structures of the newly synthesized compounds were elucidated by elemental analysis and spectral data. Some of the new compounds were tested against bacteria (Gram- ve and Gram+ ve) and fungi.

  • Source
    • "2012; 80: 789–823 microwave and conventional methods using ZnCl 2 as a catalyst. The synthesized compounds were screened for their in vitro antimicrobial activities [88]. Screening results revealed significant inhibitory activity (inhibition zone 20–25 mm) of derivatives having a 2-OCH 3 -C 6 H 4 group at second position of the thiazolidine ring against Escherichia coli, Candida albicans, and Candida parapsilosis, whereas derivatives bearing 4-NO 2 -C 6 H 4 , 2-OH-C 6 H 4 , 4-OH-C 6 H 4 , 4-OCH 3 -C 6 H 4 , 2-Cl-C 6 H 4, and 4-Cl-C 6 H 4 groups were found to have moderate activity (inhibition zone 15–20 mm) against Bacillus subtilis, Staphylococcus aureus, and Escherichia coli. "
    [Show abstract] [Hide abstract]
    ABSTRACT: 2-Mercaptobenzothiazoles are an important class of bioactive and industrially important organic compounds. These compounds are reported for their antimicrobial and antifungal activities, and are subsequently highlighted as a potent mechanism-based inhibitor of several enzymes like acyl coenzyme A cholesterol acyltransferase, monoamine oxidase, heat shock protein 90, cathepsin D, and c-Jun N-terminal kinases. These derivatives are also known to possess antitubercular, anti-inflammatory, antitumor, amoebic, antiparkinsonian, anthelmintic, antihypertensive, antihyperlipidemic, antiulcer, chemoprotective, and selective CCR3 receptor antagonist activity. This present review article focuses on the pharmacological profile of 2-mercaptobenzothiazoles with their potential activities.
    Scientia Pharmaceutica 12/2012; 80(4):789-823. DOI:10.3797/scipharm.1204-27
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A variety of N'-(4-(arylamino)-6-(pyrazin-2-ylamino)-1,3,5-triazin-2-yl)isonicotinohydrazide, 7a-j were synthesized by using 2-aminopyridine, isonicotic acid hydrazide and cyanuric chloride. And the structures of these compounds were confirmed by IR, NMR (1 H & 13 C) spectral analysis. The newly synthesized compounds were also evaluated for antimicrobial activity against variety of bacterial strains and some of these compounds have shown significant antibacterial and antifungal activities.
  • Source
    Journal of the Chilean Chemical Society 12/2008; 53(4). DOI:10.4067/S0717-97072008000400005 · 0.47 Impact Factor
Show more


Available from