Calla-Positive Acute Leukaemia with t(5q;14q) Translocation and Hypereosinophilia – A Unique Entity?

Department of Paediatrics, Free University, Berlin.
Acta Haematologica (Impact Factor: 0.99). 02/1989; 82(2):85-90. DOI: 10.1159/000205289
Source: PubMed

ABSTRACT A patient with common acute lymphoblastic leukaemia (ALL), hypereosinophilic syndrome and t(5;14) (q31.1;q32.3) translocation is described. Even with intensive treatment only short periods of complete remission were achieved. Recurrence of the leukaemia was always accompanied by the appearance of eosinophilic granulocytes in the blood and in the bone marrow. Although there is no experimental proof we assume that the hypereosinophilic syndrome is causally related to the chromosome aberration. Translocation of the GM-CSF gene from chromosome No. 5 to chromosome No. 14, might have led to the deregulation of the gene by enhancer sequences of the immunoglobulin heavy-chain region on chromosome No. 14, with the consequence of an overproduction of neutrophilic and particularly eosinophilic granulocytes. Furthermore, stimulation of the leukaemic cell clone may have occurred by this translocation. The similarity of the clinical course with cases described in the literature suggests that this condition is a unique entity of ALL.

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    • "The observation of genetic linkage to 5q31-q33 suggests that the latter chromosomal variation is unrelated to HES. Linkage to the 5q31-q33 region may be supported further by several reports of chromosomal abnormalities involving 5q31-q33 in patients with eosinophilia associated with malignancies, such as chronic myelomonocytic leukemia, acute lymphocytic leukemia, and myelodysplastic or myeloproliferative syndromes (Hogan et al. 1987; Baumgarten et al. 1989; Berkowicz et al. 1991; Yates and Potter 1991; Baranger et al. 1994; Jani et al. 1994; Matsushima et al. 1994). This also may suggest that the FE gene, or another gene located in 5q31-q33, potentially could play a role in the eosinophilia associated with these neoplastic syndromes. "
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