Pathophysiology and pathogenesis of generalized peritonitis.
ABSTRACT Peritonitis is a complex disease state that results in many pathophysiologic alterations that affect multiple organs. The clinician must possess a thorough understanding of the pathophysiology and pathogenesis of the disease so that effective treatment can be instituted. Treatment should be directed at eliminating the cause of peritonitis and preventing or reversing the resulting pathophysiologic alterations.
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Article: Septic peritonitis.[Show abstract] [Hide abstract]
ABSTRACT: Bacterial septic peritonitis is a serious condition that requires immediate treatment. The pathogenesis is complex, and the list of diagnostic differentials is extensive. The keys to successful treatment are early recognition of the condition and elimination of the causative organism. Multiple options for draining the peritoneal cavity exist, and further studies are necessary to establish specific, evidence-based guidelines. The prognosis is generally guarded in dogs and cats. Much depends on whether the patient develops concurrent sepsis, systemic inflammatory response syndrome, or multiple organ dysfunction syndrome.Compendium (Yardley, PA) 01/2010; 32(10):E1-E15. · 0.64 Impact Factor
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ABSTRACT: Dezesseis eqüinos adultos foram distribuídos aleatoriamente em 4 grupos (GI, GII, GIII e GIV), constituídos por quatro animais, recebendo cada grupo o seguinte inóculo por via intraperitoneal: GI (100 X 107 unidades formadoras de colônia (UFC) de Escherichia coli diluídos em 500ml de salina 0,9%); GII (100 X 107 UFC de Bacteroides fragilis diluídos em 500ml de salina 0,9%); GIII (100 X 107 UFC de E. coli associados a 100 X 107 UFC de B. fragilis diluídos em 500ml de salina 0,9%); GIV (testemunho - 500ml de salina 0,9%). Aumento da sensibilidade e tensão da parede abdominal, diarréia, diminuição dos sons intestinais e aumento da freqüência cardíaca foram os sinais mais freqüentemente observados nos eqüinos inoculados com cepas bacterianas. Eqüinos inoculados com culturas puras de E. coli ou B. fragilis apresentaram peritonites brandas e autolimitantes, enquanto que os inoculados com a associação dessas bactérias apresentaram sinais de maior intensidade e duração.Ciência Rural 01/1999; 29(3). · 0.38 Impact Factor
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ABSTRACT: To our knowledge, this is the first report describing the oxidant–antioxidant status in horses clinically affected with peritonitis. The present study was carried out to investigate the importance of oxidative stress markers and antioxidant parameters in the prediction of clinical outcomes of peritonitis in draft horses. Thirty-six draft horses were used in this study in the period between March 2006 and March 2009. Diagnosis of the clinical cases was based on the physical examination, clinical pathology, and necropsy. Our results showed that there was a significant increase (p < 0.05) in the level of malondialdehyde (MDA) of nonsurvivors in comparison with that of survivors. There was, however, a significant decrease (p < 0.05) in the activity of superoxide dismutase, catalase, reduced glutathione, vitamin C, and nitric oxide (NO). Analysis of receiver operating characteristic indicated a high sensitivity (90%) and specificity (86.71%) of MDA level (p < 0.001) to predict the outcome of peritonitis. Results of peritoneal fluid analysis revealed an abnormal physical appearance with a significant increase (p < 0.05) in total leukocytic counts and total protein levels. In conclusion, our findings might indicate that lipid peroxide levels and antioxidant parameters could have a prognostic significance in draft horses showing peritonitis.Comparative Clinical Pathology 01/2010;