Lung function and postural changes during pregnancy

Aarhus University Hospital, Aarhus, Central Jutland, Denmark
Respiratory Medicine (Impact Factor: 3.09). 12/1989; 83(6):467-70. DOI: 10.1016/S0954-6111(89)80127-1
Source: PubMed


The aim of this study was to determine the effects of postural changes on lung function in pregnant women during the first, second, third trimester and post partum. A significant decrease in FRC, PEF and FEV1 was observed as a result of the postural changes. Arterial oxygenation, MVV and DLCO remained largely the same.

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    • "In each study, two to four diffusion tests were performed per session. DL CO decreased by 10–15% in the second and third trimester in both singleton and twin pregnancies compared to the first trimester and post-partum (Gazioglu et al., 1970; McAuliffe et al., 2002; Norregaard et al., 1989). Greater resistance to diffusion through the alveolar membrane (DM) and not a decrease in pulmonary capillary blood volume (Vc) accounted for the decrease in DL CO (Gazioglu et al., 1970). "
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    ABSTRACT: In conclusion, it is important to appreciate the anatomic and physiologic adaptations in pregnancy in order to accurately diagnose and treat cardiopulmonary disease states in the gravid woman. Without knowing what constitutes normalcy in pregnancy, inappropriate diagnosis and interventions may occur. Furthermore, this knowledge is fundamental for understanding how disease states affect pregnancy and how pregnancy affects disease.
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    ABSTRACT: We have measured arterial oxygen saturation (SpO2) continuously overnight in 13 non-pregnant (NP), 13 pregnant normotensive (NPIH) and 15 pregnant patients with a diagnosis of pregnancy-induced hypertension (PIH). The two pregnant groups did not differ in duration of pregnancy (> 35 weeks) and none was in labour. There was no significant difference in age between these three groups. Mean SpO2 in group NP was 98.5% (range 97-99%). This was significantly higher than that in group NPIH (95.2 (91-98) %) and group PIH (94.9 (89-99) %). In seven pregnant patients, more than 20% of the recording was spent with an SpO2 < 90%. We conclude that a significant number of pregnant women (> 35 weeks' gestation) suffer from prolonged nocturnal hypoxaemia.
    BJA British Journal of Anaesthesia 12/1995; 75(6):678-82. DOI:10.1093/bja/75.6.678 · 4.85 Impact Factor
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