Evaluation of the retrograde contamination guard in a bacteriologically challenged rabbit model.
ABSTRACT We compared a newly developed closed urinary drainage system incorporating a retrograde contamination guard (RCG) with the conventional closed drainage system. The new system contains a solid bactericide (povidone iodine) pellet enclosed in a porous cartridge at the drain port of the urine collection bag. A catheterised rabbit model was used. The urine drainage bags were challenged daily for 8 days with an auxotrophically marked uropathogenic strain of Escherichia coli at the outlet tube. The bag urine was infected with the marked organism in 10 of the 11 rabbits in the control group (conventional collection bags) in 3.8 +/- 1.03 days and in only 1 of the 13 rabbits fitted with the RCG. The RCG effectively prevents contamination of the urine drainage bag and thus may play an important role in reducing the incidence of nosocomial urinary tract infections.
- New England Journal of Medicine 06/1966; 274(21):1155-61. · 51.66 Impact Factor
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ABSTRACT: A bacteriologically-stressed catheterized animal model was developed to evaluate the comparative importance of the intraluminal versus the extraluminal route of catheter-acquired urinary tract infections. This study indicated that in short-term catheterization (less than 7 days), contamination of the drainage spout or accidental disconnection of the drainage tube resulted in bacteriuria within a short time (32-48 hours). If a strict sterile closed drainage system was maintained, the extraluminal route assumed more importance in the development of bacteriuria, however this pathway was considerably slower (72-168 hours). It appeared that catheter-associated bacteriuria results from ascending bacterial colonization within glycocalyx-enclosed biofilm on the inside and/or outside surfaces of the catheter and drainage systems. Development of a biomaterial that inhibits bacterial adherence and does not allow upstream colonization of bacteria on the catheter drainage system would significantly influence the rate of catheter-acquired urinary tract infection.Urology 11/1985; 26(4):369-75. · 2.42 Impact Factor
- New England Journal of Medicine 09/1974; 291(5):215-9. · 51.66 Impact Factor