Treatment of photodamaged facial skin with topical tretinoin.
ABSTRACT A 6-month, randomized, double-blind, vehicle-controlled study was conducted with 0.05% tretinoin cream once daily in the treatment of photodamaged facial skin. Significant amelioration of many of the signs of photodamage were achieved with minimal side effects. Clinical grading showed significant improvement both in the assessments based on changes in clinical scores and in pre- and posttreatment comparisons of standardized photographs. Fine wrinkling, coarse wrinkling, sallowness, looseness, and hyperpigmentation were significantly improved with tretinoin therapy. Furthermore, a self-appraisal questionnaire indicated that tretinoin-treated patients, but not vehicle-treated patients, were able to perceive improvement in their facial appearance. An objective method based on digital image processing of silicone rubber casts obtained from the crow's-feet area also indicated that the skin surface topography was smoother and less wrinkled in the tretinoin-treated group compared with the vehicle-control group.
Article: Facial anti-wrinkle cream: influence of product presentation on effectiveness: a randomized and controlled study.[show abstract] [hide abstract]
ABSTRACT: The great interest in eternal youth has developed a large market for skin care products claiming anti-wrinkle effects. A high-priced luxurious anti-wrinkle cream dispensed in its original packaging and in a neutral jar, were compared with the effects from a regular moisturizing face cream in a luxurious jar. Eighty Swedish women aged 35-64 years were randomly divided into three groups; group A treated their facial skin for 6 weeks with the expensive cream in its luxury jar, B used a regular moisturiser filled in the luxury jar, and C used the expensive cream filled in a neutral jar. Evaluation was made by the subjects, clinical evaluation by a trained observer, and measurement of skin surface relief by optical profilometry. Participants using jars A and B consumed more product than participants using jar C, and the luxury jar thus resulted in better compliance. There were no significant differences between the three groups relating to the effects on wrinkles and smoothness, nor in subject assessment of their skin feeling younger or more beautiful. Facial appearance was the same. Profilometry showed reduced surface microrelief with all products. The present study conducted as a formal trial could not verify a claim of anti-wrinkle effect of a known prestigious product. Surprisingly, there was no systematic effect on subjective and objective cosmetic parameters of the luxury packaging, except a better compliance. Product appreciation by consumers may, however, be different in spontaneous use not biased by study conditions.Skin Research and Technology 06/2007; 13(2):189-94. · 1.71 Impact Factor
[show abstract] [hide abstract]
ABSTRACT: Photoaging is the superposition of photodamage (ultraviolet [UV] radiation-induced) on the aging process. It is a major damaging consequence of free radical action. Curcumin (diferuloylmethane) is a phytochemical with diverse antioxidant and antiinflammatory properties. However, it shows a poor topical bioavailability. Therefore, we encapsulated curcumin in elastic vesicles (EVs) and investigated different doses (1, 3, 5 and 10 micromol) for its in vivo antiaging activity in mice. VICCO turmeric served as the marketed control, and free curcumin dispersed in an ointment base was another control. The dorsal depilated skin surface was exposed to the whole UV range for 5 sec, five times a week for 6 weeks. Each exposure was followed by treatment with encapsulated curcumin (at different doses), free curcumin ointment, and VICCO turmeric. The effectiveness was established in terms of macroscopic and histopathological evaluation of skin, pinch test, and redox homeostasis of skin homogenates. Skin evaluation demonstrated that 5- and 10-micromol doses of curcumin EVs and the marketed formulation were effective in preventing the formation of lesions and other changes. The pinch test showed that the reduction in recovery time with the 10-micromol dose of curcumin EVs was highly significant (p < 0.05). Histopathological studies further confirmed the protective role of curcumin EVs. The normal redox balance was restored with a 10-micromol dose, whereas a 5-micromol dose and the marketed formulation showed significant and equivalent activity. The free curcumin ointment group showed no improvement in redox levels. This study provides the first preclinical evidence for the use of topically delivered curcumin to attenuate photoaging.Rejuvenation Research 08/2010; 13(4):397-410. · 3.83 Impact Factor
Article: Alstonia scholaris R. Br. Significantly Inhibits Retinoid-Induced Skin Irritation In Vitro and In Vivo.[show abstract] [hide abstract]
ABSTRACT: Topical retinoids inhibit matrix metalloproteinases and accelerate collagen synthesis, thereby triggering antiaging effects in the skin. However, topical retinoids can cause severe skin reactions, including scaling, erythema, papules, and inflammation. The present study demonstrates that the ethanolic bark extract of Alstonia scholaris R. Br. can significantly inhibit all-trans retinoic acid-induced inflammation in human HaCat keratinocyte cells. Furthermore, two representative retinoid-induced proinflammatory cytokines, monocyte chemoattractant protein-1 and interleukin-8, were significantly suppressed by A. scholaris extract (by 82.1% and 26.3% at 100 ppm, and dose-dependently across the tested concentrations) in vitro. In a cumulative irritation patch test, A. scholaris extract decreased retinol-induced skin irritation, while strengthening the ability of retinoids to inhibit matrix metalloproteinase-1 expression, which is strongly associated with aging effects. These results suggest that A. scholaris is a promising compound that may increase the antiaging function of retinoids while reducing their ability to cause skin irritation.Evidence-based Complementary and Alternative Medicine 01/2012; 2012:190370. · 4.77 Impact Factor