Article

Treatment of photodamaged facial skin with topical tretinoin.

Department of Dermatology, University of Pennsylvania, Philadelphia.
Journal of the American Academy of Dermatology (impact factor: 3.99). 10/1989; 21(3 Pt 2):638-44. pp.638-44
Source: PubMed

ABSTRACT A 6-month, randomized, double-blind, vehicle-controlled study was conducted with 0.05% tretinoin cream once daily in the treatment of photodamaged facial skin. Significant amelioration of many of the signs of photodamage were achieved with minimal side effects. Clinical grading showed significant improvement both in the assessments based on changes in clinical scores and in pre- and posttreatment comparisons of standardized photographs. Fine wrinkling, coarse wrinkling, sallowness, looseness, and hyperpigmentation were significantly improved with tretinoin therapy. Furthermore, a self-appraisal questionnaire indicated that tretinoin-treated patients, but not vehicle-treated patients, were able to perceive improvement in their facial appearance. An objective method based on digital image processing of silicone rubber casts obtained from the crow's-feet area also indicated that the skin surface topography was smoother and less wrinkled in the tretinoin-treated group compared with the vehicle-control group.

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Keywords

able
 
crow's-feet area
 
digital image processing
 
facial appearance
 
minimal side effects
 
objective method
 
perceive improvement
 
photodamaged facial skin
 
pre-
 
self-appraisal questionnaire
 
Significant amelioration
 
silicone rubber casts
 
skin surface topography
 
standardized photographs
 
tretinoin therapy
 
tretinoin-treated group
 
tretinoin-treated patients
 
vehicle-controlled study
 
vehicle-treated patients
 

J J Leyden