Brenner tumor of the ovary: a correlative histologic, histochemical, immunohistochemical, and ultrastructural investigation.
ABSTRACT The histologic, histochemical, immunohistochemical, and ultrastructural features of Brenner tumor (BT) were studied. BT was compared with transitional bladder cells, and close similarities between the two tissues were identified. Abundant glycogen in all cellular layers, an alcianophilic/sialomucinic surface mucous coat, and argyrophilic cells characterized both BT and bladder epithelium. Immunohistochemically, chromogranin and neuron-specific enolase reactivity was observed in all cases examined. An additional relevant finding was the presence of serotonin-storing cells in both BT and urothelium. Moreover, carcinoembryonic antigen, epithelial membrane antigen, and keratin reaction were found in BT and urothelium, indicating an additional antigenic similarity. Additionally, malignant Brenner tumor was ultrastructurally found to share many common features with the bladder tissue. The distinct histochemical, ultrastructural, and antigenic pattern of BT, primarily of the transitional type, is emphasized.
- [Show abstract] [Hide abstract]
ABSTRACT: Transitional cell tumours constitute a rare group of ovarian epithelial neoplasms, first described in 1932 and still the subject of many studies to determine their histogenesis and endocrine activity. They are classified into two distinct clinicopathological categories: Brenner tumours (benign, borderline or proliferative and malignant) and transitional cell carcinoma. We report a case of a large, bilateral benign Brenner tumour associated with mucinous cystadenoma in a 54 year old woman with a history of breast carcinoma. The main clinical and pathological features of transitional cell ovarian tumours are described and their association with mucinous tumours is discussed.04/2011; 44(2):83-87. DOI:10.1016/j.patol.2011.02.001
- [Show abstract] [Hide abstract]
ABSTRACT: To determine whether Brenner tumors and transitional cell carcinomas (TCCs) of the ovary are urothelial in type, the immunoprofiles of 14 Brenner tumors, including three malignant examples, and eight ovarian TCCs were compared with those of Walthard nests, urothelium, 12 urinary bladder TCCs and 17 ovarian adenocarcinomas (serous, endometrioid, mucinous, and undifferentiated type). The immunohistochemical stains used included those for cytokeratins CKs 5/6, CK7, CK8, CK13, and CK20, vimentin, CA125, and the specific urothelial differentiation marker uroplakin III. CK7 and CK8 were broadly expressed in most tumors of ovary and bladder examined, while vimentin was focally present in some ovarian TCCs and adenocarcinomas. As in normal and neoplastic bladder urothelium, urothelial markers, including uroplakin III, CK13, and CK20, were detected in the epithelial nests of Brenner tumors. Brenner tumor cells also expressed uroplakins Ia and II. CA125 was observed focally in some Brenner tumors. In contrast, TCCs of the ovary and Walthard nests lacked uroplakins and were essentially negative for CK20 and CK13 but quite strongly expressed CA125. This immunophenotype closely resembled that found in ovarian adenocarcinomas. Thus, it appears that the only true urothelial-type ovarian neoplasm is the Brenner tumor, whereas ovarian TCC most likely represents a poorly differentiated adenocarcinoma with a morphologic transitional cell pattern. These results may explain the controversies as expressed in the recent literature concerning TCC of the ovary and establish its place among the ovarian adenocarcinomas of müllerian type.Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin 03/2001; 438(2):181-91. DOI:10.1007/s004280000315 · 2.56 Impact Factor
Article: Brenner tumor of the vagina[Show abstract] [Hide abstract]
ABSTRACT: Two cases of Brenner tumor of the vagina were encountered in postmenopausal asymptomatic women who presented with polypoid lesions measuring 0.5 and 1.2 cm, respectively, in the upper and mid-vagina. DNA flow cytometry in one tumor showed a diploid histogram, and Ki-67 (MIB-1) proliferation marker was very low in both tumors. To the best of our knowledge, only two vaginal Brenner tumors have been previously reported. Transition between the vaginal surface epithelium and the tumor in one of our cases may support a metaplastic mullerian origin for these tumors.International Journal of Gynecological Pathology 02/1998; 17(1):79-82. DOI:10.1097/00004347-199801000-00014 · 1.63 Impact Factor