The Functioning and Well-being of Depressed Patients: Results From the Medical Outcomes Study

Department of Psychiatry and Biobehavioural Sciences, University of California, Los Angeles, Los Ángeles, California, United States
JAMA The Journal of the American Medical Association (Impact Factor: 30.39). 09/1989; 262(7):914-9. DOI: 10.1001/jama.1989.03430070062031
Source: PubMed

ABSTRACT We describe the functioning and well-being of patients with depression, relative to patients with chronic medical conditions or no chronic conditions. Data are from 11,242 outpatients in three health care provision systems in three US sites. Patients with either current depressive disorder or depressive symptoms in the absence of disorder tended to have worse physical, social, and role functioning, worse perceived current health, and greater bodily pain than did patients with no chronic conditions. The poor functioning uniquely associated with depressive symptoms, with or without depressive disorder, was comparable with or worse than that uniquely associated with eight major chronic medical conditions. For example, the unique association of days in bed with depressive symptoms was significantly greater than the comparable association with hypertension, diabetes, and arthritis. Depression and chronic medical conditions had unique and additive effects on patient functioning.

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    • "Variability may also be related to the following factors: (1) differences in type of cancer (depression rates are generally highest in pancreatic, oropharyngeal, and breast carcinomas ; and lowest in lymphoma, leukaemia, and gastric cancers (McDaniel et al., 1995)), (2) staging (Newport & Nemeroff, 1998), (3) severity of illness (rates of depression tend to increase with increase disease severity (Ciaramella & Poli, 2001)), and (4) type of treatment (anti-cancer treatments frequently associated with depression include cytokines (Musselman et al., 1998; Newport & Nemeroff, 1998; Capuron et al., 2001; Musselman et al., 2001a, McDaniel et al., 1997). Depression has a negative impact on outcome in cancer diagnoses in general (Wells et al., 1989). "
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    ABSTRACT: Abstract Depression, ranging from mild to severe, is the most frequently found psychological symptom among individuals with cancer. Depression in cancer patients has been known to mitigate emotional distress, quality of life, adherence to medical treatment, and overall health outcomes. Specifically, depression has been associated with impaired immune response and with poorer survival in patients with cancer. Various studies have found that psychotherapeutic interventions are effective in reducing symptoms of depression, which in turn could affect disease progression and mortality. This paper provides updated information on psychotherapeutic interventions geared towards cancer patients suffering from depressive disorders, and its impact on disease progression. PubMed, Cochrane Library database, PsycINFO and PsycARTICLES databases were searched from January 1980 through August 2013 using key words: psychotherapy, treatment, oncology, cancer, psycho-oncology, psychosocial issues, psychosocial stress, depression, mood disorder, and psychoneuroimmunology.
    International Review of Psychiatry 02/2014; 26(1):31-43. DOI:10.3109/09540261.2013.864259 · 1.80 Impact Factor
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    • "Depression reduces the overall well being and functioning of human beings (Goldney et al., 2000; Hays et al., 1995; Wells et al., 1989). It also increases economic burden and loss of working days thereby creating high morbidity rates (Greenberg and Birnbaum, 2005; Paykel et al., 2005). "
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    • "Additionally, because of the severity and chronic course of depression in diabetic patients, 80% of them may experience depression relapse even after successful treatment [22]. Once chronic medical illness appears, comorbid depression increases the burden of symptoms and functional disability [23] [24]. "
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    ABSTRACT: There is a bidirectional adverse association between diabetes and depression. The odds for experiencing depressive symptoms in diabetic patients are two times more than nondiabetic persons, and depression is an independent predictor for the onset of diabetes. However, depression has been approximately unrecognized and untreated in two-thirds of diabetic patients, which may lead to worsened diabetes complications. A cornerstone strategy for managing depression among diabetic patients is the use of diet to improve both health problems. Because of similar pathophysiology for chronic diseases and depression, it seems that similar dietary recommendations could be useful. However, few studies have been conducted among diabetic patients. Regarding the complications of diabetes such as renal diseases and coronary heart diseases, the proper range of various macronutrients should be clarified in depressed diabetic patients as well as the proper type of each macronutrient. In this paper, we reviewed the available data on the treatment of depression in diabetic patients.
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