Juvenile colloid milium. Immunohistochemical and ultrastructural studies
ABSTRACT A 7-year-old Italian girl with juvenile colloid milium was studied with histological, immunohistochemical, and electron microscopic methods. This patient had a well-documented history of severe sunburn and developed the lesions on the face shortly afterward. Numerous apoptotic keratinocytes were observed in the lower epidermis. These cells began their degeneration with filamentous whorl formation (or filamentous degeneration) of tonofilaments. In the papillary dermis the colloid substance was resolved by the electron microscopy into either wavy, thin filaments derived from the epidermal keratinocytes or typical amyloid filaments. Many desmosomes and gap junctions were found in the colloid substance. Polyclonal antikeratin antibody (DAKO) was positive in the colloid substance, particularly in the parts close to the epidermis. These findings suggested that juvenile colloid milium is different from adult colloid milium despite clinical similarities and that the former belongs to the group of actinic amyloid K, i.e. amyloidoses due to actinic degeneration of keratinocyte and its keratin.
Article: Ligneous conjunctivitis.[Show abstract] [Hide abstract]
ABSTRACT: The case history is given of a woman of 65 (in 1973) with a granulomatous conjunctival inflammation in the right eye and chronic recurrent polyps on the vocal cords. Several times, granulomatous tissue was removed from the conjunctiva of the right eye but the result was recurrences at shorter intervals. Seven years after the onset in the right eye the left eye became affected. Various treatments, both systemic and local, were tried without success. The histological diagnosis of ligneous conjunctivitis was not made until 1981. Treatment with the known remedies for ligneous conjunctivitis was not successful. At the end of 1984 treatment with Imuran (azathioprine) was started. Since that time the patient has been practically free of recurrent granulomatous tissue on the conjunctiva and vocal cords. The treatment of ligneous conjunctivitis with Imuran has not previously been reported in the literature.Documenta Ophthalmologica 01/1987; 64(1):5-11. DOI:10.1007/BF00166679 · 1.11 Impact Factor
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ABSTRACT: We report the clinical, histological and ultrastructural features of juvenile colloid milium affecting a brother and sister. In this rare condition, translucent papules develop on sun-exposed areas of skin, with onset in childhood. Histologically and ultrastructurally, the papules consist of amyloid-like material derived from epidermal keratonocytes. A review of the literature suggests a possible genetic abnormality that leads to sun-induced degeneration of keratinocytes.Journal of Cutaneous Pathology 11/1992; 19(5):434-8. DOI:10.1111/j.1600-0560.1992.tb00617.x · 1.56 Impact Factor
Article: UV-induced colloid milium[Show abstract] [Hide abstract]
ABSTRACT: A 39-year-old woman is reported who developed numerous confluent yellowish semitranslucent papules of the face over 8 months. The patient habitually exposed herself to UVA-radiation twice a week for 7 years for aesthetic reasons. Histological, histochemical and immunohistochemical examinations were consistent with the diagnosis of adult colloid milium. A review of the literature is discussed. This case emphasizes the close relationship between long-term sun exposure, solar elastosis and adult colloid milium.Clinical and Experimental Dermatology 08/1993; 18(4):347-50. DOI:10.1111/j.1365-2230.1993.tb02215.x · 1.23 Impact Factor