Juvenile colloid milium. Immunohistochemical and ultrastructural studies.
ABSTRACT A 7-year-old Italian girl with juvenile colloid milium was studied with histological, immunohistochemical, and electron microscopic methods. This patient had a well-documented history of severe sunburn and developed the lesions on the face shortly afterward. Numerous apoptotic keratinocytes were observed in the lower epidermis. These cells began their degeneration with filamentous whorl formation (or filamentous degeneration) of tonofilaments. In the papillary dermis the colloid substance was resolved by the electron microscopy into either wavy, thin filaments derived from the epidermal keratinocytes or typical amyloid filaments. Many desmosomes and gap junctions were found in the colloid substance. Polyclonal antikeratin antibody (DAKO) was positive in the colloid substance, particularly in the parts close to the epidermis. These findings suggested that juvenile colloid milium is different from adult colloid milium despite clinical similarities and that the former belongs to the group of actinic amyloid K, i.e. amyloidoses due to actinic degeneration of keratinocyte and its keratin.
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ABSTRACT: : Lipoid proteinosis is a rare autosomal recessive deposition disorder due to loss-of-function mutations in the gene encoding extracellular matrix protein 1 on chromosome 1q21. There are limited case reports of lipoid proteinosis in the Chinese population. The authors report 1 case of lipoid proteinosis in a Chinese patient with typical clinical and histopathological manifestations. Physical examination in this patient demonstrated hoarse voice, hypertrophy of tongue and lips, inability to fully protrude the tongue, and cutaneous features including moniliform blepharosis, verrucous plaques, and scarring. Biopsies from the eyelid, pharyngeal mucosa, and elbow lesions revealed diffuse amorphous deposits of hyaline material within the dermis and around blood vessels, which stained positively for periodic acid-Schiff, was diastase resistant and stained negatively on Congo red.The American Journal of dermatopathology 02/2014; · 1.30 Impact Factor
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ABSTRACT: Caso clínico Dermatología Rev Mex 2009;53(1):26-30 RESUMEN El milium coloide es una enfermedad cutánea muy rara, que se distingue por depósitos de material amorfo en la dermis. Existen cuatro tipos clínicos: 1) milium coloide del adulto, 2) milium coloide juvenil, 3) degeneración nodular coloide y 4) milium coloide pigmentado. El milium coloide juvenil aparece antes de la pubertad y es heredable; desde el punto de vista histopatológico se distingue del milium coloide del adulto. Se informan dos casos de milium coloide: uno juvenil y otro del adulto. Palabras clave: milium coloide juvenil, milium coloide del adulto, histopatología. ABSTRACT Colloid milium is a rare skin condition characterized by deposition of amorphous material in the dermis. There are four clinical types: Adult and juvenile types, nodular colloid degeneration and pigmented colloid milium. Juvenile colloid milium presents before puberty, may be inherited and it can be distinguished histologically from the adult form. We present two cases: an adult and a juvenile type. Key words: juvenile colloid milium, adul colloid milium, histology.01/2009;
- Piel 02/2013; 28(2):78–80.