Article

Digestion of killed Paracoccidioides brasiliensis by neutrophils.

Section of Immunology I, Instituto de Biomedicina, Central University of Venezuela, Caracas.
Mycopathologia (impact factor: 1.65). 05/1989; 106(1):53-8. DOI:10.1007/BF00436927 pp.53-8
Source: PubMed

ABSTRACT We previously described an in vitro assay showing that neutrophils (PMNs) from patients with paracoccidioidomycosis (PARA) have a specific digestive deficiency against suspensions of live Paracoccidioides brasiliensis. We now report that this defect is equally detectable against autoclaved, but not Amphotericin B-killed P. brasiliensis. The use of autoclaved suspensions facilitates the use of our in vitro assay. It might allow the development of an in vitro intradermal test for digestion of fungi. Differential digestive ability of phagocytes against live (or autoclaved) and Amphotericin-B killed fungi is of conceptual interest. It may be relevant in understanding therapeutic effect of Amphotericin B.

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Keywords

Amphotericin B
 
Amphotericin B-killed P. brasiliensis
 
Amphotericin-B
 
autoclaved
 
autoclaved suspensions facilitates
 
conceptual interest
 
Differential digestive ability
 
fungi
 
neutrophils
 
Paracoccidioides brasiliensis
 
paracoccidioidomycosis
 
specific digestive deficiency
 
understanding therapeutic effect
 
vitro assay
 
vitro intradermal test
 

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