Anti-inflammatory & anti-ulcerogenic activity of amentoflavone

The Indian Journal of Medical Research (Impact Factor: 1.4). 07/1987; 85(6):689-93.
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    • "Furthermore, it has been proposed that gastric acid is essential for esophageal mucosal damage (Bell et al., 1992). It appeared to have anti-ulcerogenic properties in rats and guinea pigs, and such properties are of interest with respect to the adverse effect of gastric ulceration, which commonly develops in subjects taking anti-inflammatory drugs (Gambhir et al., 1987). Flavonoids are potent bioactive molecules and have been proposed to have antioxidative and modulatory effects in cells and anti-inflammatory and anticancer properties. "
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    ABSTRACT: It was evaluated the inhibitory action of quercetin-3-O-beta-D-glucuronopyranoside (QGC) on reflux esophagitis and gastritis in rats. QGC was isolated from the herba of Rumex Aquaticus. Reflux esophagitis or gastritis was induced surgically or by administering indomethacin, respectively. Oral QGC decreased ulcer index, injury area, gastric volume, and acid output and increased gastric pH as compared with quercetin. Furthermore, QGC significantly decreased gastric lesion sizes induced by exposing the gastric mucosa to indomethacin. Malondialdehyde levels were found to increase significantly after inducing reflux esophagitis, and were reduced by QGC, but not by quercetin or omeprazole. These results show that QGC can inhibit reflux esophagitis and gastritis in rats.
    Korean Journal of Physiology and Pharmacology 08/2009; 13(4):295-300. DOI:10.4196/kjpp.2009.13.4.295 · 1.38 Impact Factor
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    • "The biological and pharmacological properties of flavonoids cover a wide spectrum, ranging from beneficial to harmful health effects. The literature describes flavonoids as anti-oxidative [Hanasaki et al., 1994], anti-apoptotic [Quadri et al., 2000], anti-inflammatory [Clavin et al., 2007], anti-mutagenic [Wall, 1992], anti-ulcerogenic [Gambhir et al., 1987], and anti-anxiolytic [Baureithel et al., 1997]. However, many other studies indicate that particular flavonoids can also display mutagenic and genotoxic activities in bacterial assays [Ertrurk et al., 1984; Starvic et al., 1984; Czeczot et al., 1990; Jurado et al., "
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    ABSTRACT: Cell-free and bacterial assays indicate that flavonoid-enriched fractions and the flavonoids of pepper tree stem bark from Schinus terebinthifolius Raddi have genotoxic rather than antigenotoxic properties. In the present report, we have examined the ability of flavonoid-enriched fractions to damage plasmid DNA and the repair pathways involved in the recognition of these DNA lesions. High concentrations of two flavonoid-enriched fractions were able to break phosphodiester bonds in DNA. In addition, studies using bacterial strains deficient in nucleotide excision repair and base excision repair (BER) enzymes indicated that the flavonoid-enriched fractions generated lesions that were substrates for enzymes belonging to the BER pathway. In addition, in vitro studies indicated that the DNA damage produced by the flavonoid-enriched fractions was also a substrate for exonuclease III and that the phosphodiester breakage was amplified by copper ions. These results indicate that flavonoids from the pepper tree (Schinus terebinthifolius, Raddi) generate lesions on DNA that are potential targets of FPG and MutY glycosylase from the BER pathway. Chromatographic and spectral analyses helped to support the hypothesis that the flavonoids of the Brazilian pepper tree bark are the main factors involved in the fraction's damage potential. The isolated flavonoids from Fraction II were also tested in vitro and support the oxidative damage potential of these flavonoids.
    Environmental and Molecular Mutagenesis 10/2007; 48(8):672-81. DOI:10.1002/em.20334 · 2.63 Impact Factor
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    • "E-mail: et al., 2005), inhibit NF-KB activation in macrophages (Woo et al., 2005), phospholipase C1 (Lee et al., 1996) and cAMP-dependent phosphodiesterase (Saponara et al., 1998), release Ca 2+ in skeletal muscle sarcoplasmic reticulum (Suzuki et al., 1999), and exhibit antiinflammatory (Gambhir et al., 1987), antioxidant activity (Huguet et al., 1990), antiplasmodial and leishmanicidal activities (Junert et al., 2008). To the best of our knowledge, there is no research about the hypolipidemic and hepatoprotective activity of AF. "
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    ABSTRACT: Amentoflavone (AF) isolated from Selaginella tamariscina was screened for antioxidant activities in vitro, and lowering blood lipid and hepatoprotective activity in vivo. AF had no antioxidant activity in DPPH and ABTS assay and poor reducing power in FRAP assay. Intragastric administration of AF (75 mg/kg body weight per day), ethyl acetate fraction of S. tamariscina (STEA) (150 mg/kg) and acidic extract of S. tamariscina (STAE) (150 mg/kg) to groups of hyperlipidemia mice for 21 days, they all significantly decreased the level of blood triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) in serum. The level of blood high-density lipoprotein cholesterol (HDL-C) significantly increased (P<0.001). Intragastric administration of AF (200 mg/kg body weight per day), AF (100 mg/kg), and AF (50 mg/kg) to mice injected with carbon tetrachloride to induce acute hepatic injury for 8 days, the level of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in group of AF (200 mg/kg) significantly decreased (P<0.001). The level of hepatic malondialdehyde (MDA) in groups of AF (200, 100, and 50 mg/kg, respectively) significantly decreased (P<0.001), and the level of hepatic SOD only in group of AF (200 mg/kg) significantly increased (P<0.01). The result showed that AF had a high hypolipidemic activity and hepatoprotective effect in vivo.
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