[Show abstract][Hide abstract] ABSTRACT: The natural history of inflammatory breast cancer and the recent advances in its management were reviewed.
The English medical literature from 1924 to 1990 was reviewed using the Cancerline and Medline retrieval systems, and through a manual review of bibliographies of identified articles.
The majority of patients with inflammatory breast cancer treated only with local therapies died 18 to 24 months after diagnosis. A combined modality approach with chemotherapy, surgery, and radiation therapy has improved disease-free and overall survival rates for inflammatory breast cancer. Approximately 35% to 55% of patients treated with combined modality regimens remain disease-free and alive at 5 years.
Induction combination chemotherapy administered with radiation therapy, mastectomy, both, or with additional chemotherapy favorably alters the natural history of inflammatory breast cancer. New drug combinations and high-dose chemotherapy with autologous bone marrow support are being evaluated to improve further patient survival.
Journal of Clinical Oncology 07/1992; 10(6):1014-24. · 18.43 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: We report a case of inflammatory breast cancer in an 11-year-old girl. She was treated with chemotherapy, surgery and radiotherapy, followed by intensification and autologous bone marrow transplantation. She relapsed 8 months after the end of treatment and died 2 months later with polymetastatic disease. Genetic studies did not identify any mutation of the p53 gene. Sixty-four cases of breast cancer in patients under 18 years have been reported. Thirty-eight were sufficiently described to be discussed. In two-thirds of patients, pathologic examination showed a secretory juvenile carcinoma. Prognosis in this group was good with only one death reported. In the other patients, poorly differentiated or inflammatory carcinomas were described. Mortality in this group is high. Well differentiated carcinoma were reported in two patients. Paediatric breast cancer appears to be different from the adult disease with regard to history, sex ratio and prognosis. Therapeutic implications are discussed.
The Breast 08/1996; 5(4-5):277-281. DOI:10.1016/S0960-9776(96)90026-0 · 2.38 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Inflammatory breast cancer is an aggressive subtype of invasive breast cancer. Early attempts to control the disease with local treatment modalities alone had a minimal impact on survival. More recently, multimodality treatment approaches that integrate systemic chemotherapy, surgery, and radiotherapy have resulted in improved local disease control and prolonged survival. Better systemic therapies need to be developed since metastatic disease develops in the majority of patients.
Seminars in Surgical Oncology 09/1996; 12(5):352-63. DOI:10.1002/(SICI)1098-2388(199609/10)12:5<352::AID-SSU11>3.0.CO;2-R
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