Extramammary Pagetʼs Disease of the Oral Mucosa with In Situ Carcinoma of Minor Salivary Gland Ducts
ABSTRACT This paper describes a case of oral extramammary Paget's disease associated with widespread in situ carcinoma of minor salivary gland ducts and invasive, poorly differentiated carcinoma. Clinically, the case was characterized by unusually extensive and rapidly spreading erythroplakia of the oral mucosa, accompanied by a relatively small invasive salivary gland carcinoma. Despite the similarities of breast and salivary tissue, oral extramammary Paget's disease appears to be extremely rare.
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ABSTRACT: We examined 32 cases (38 lesions) of extramammary Paget's disease (EMPD) in relation to comparative studies on intraductal carcinoma of the breast (ductal carcinoma in situ, DCIS) and apocrine adenocarcinoma (AAC). Lesions included scrotum (18 lesions), vulva (8), axilla (6), groin (3), penis (2) and chest wall (1), and the distribution was compatible with that of apocrine or supernumerary mammary glands. Histologically, extra-mammary Paget's and DCIS cells exhibited a large amount of a pale-stained cytoplasm. The cytoplasm of AAC cells frequently contained granules, was eosinophilic and differed from that of Paget's or DCIS cells. Immunohistochemical studies revealed positive reactions for polyclonal and monoclonal antibodies to carcinoembryonic antigen in all EMPD and most DCIS, but not in AAC. Recent studies have shown that extramammary Paget's cells exhibit characteristics of glandular epithelial cells and that most cases of EMPD are not accompanied by an underlying carcinoma. The results obtained in this study, coupled with data on the frequency of the supernumerary breasts, lead to the speculation that extramammary Paget's cells originate from ectopic mammary glands or from pluripotential germinative cells in the epidermis, capable of differentiating toward the mammary glands.Journal of Cutaneous Pathology 11/1990; 17(5):257-65. DOI:10.1111/j.1600-0560.1990.tb00099.x · 1.56 Impact Factor
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ABSTRACT: The clinicopathologic features of the cases of three patients with intraductal carcinoma of major salivary gland are described. As in the breast, these lesions of salivary ducts appear to represent an in situ or preinvasive phase of the disease. On follow-up, one patient had a local recurrence, and in another patient, the tumor subsequently became invasive. This experience suggests that wide surgical excision (preferably total parotidectomy) may be curative but that resections limited to grossly visible disease will result in local recurrence and/or the development of invasive ductal adenocarcinoma.Cancer 03/1992; 69(3):609-14. · 4.90 Impact Factor
Article: Salivary duct carcinoma[Show abstract] [Hide abstract]
ABSTRACT: Salivary duct carcinoma is an uncommon malignant tumor that occurs mainly in the parotid gland of elderly men. The 11 cases of salivary duct carcinoma which are included in this study occurred in older men (mean age 56 years) and were located in the parotid (7), submandibular salivary gland (2), and the minor salivary glands in the maxilla (2). The maximum tumor dimension ranged from 3 to 9 cm. Microscopically, all had infiltrating margins, with circumscribed groups of epithelial cells arranged in various patterns; the invasive component was embedded in a desmoplastic stroma. Perineural invasion and lymph node metastasis were noted in seven and three cases, respectively, at the time of initial surgery. Radical surgery was offered to ten patients and postoperative radiotherapy to nine patients. Salivary duct carcinoma appears to be an aggressive tumor with distinctive histological features, which has not been described in the minor salivary glands of the maxilla to date. The clinicopathologic features of these tumors are presented, with a review of the literature.Journal of Surgical Oncology 11/1993; 54(3):193-8. DOI:10.1002/jso.2930540315 · 2.84 Impact Factor