Article

Production and secretion of immunoreactive growth hormone-releasing factor by pheochromocytomas.

Cancer (impact factor: 4.77). 06/1986; 57(9):1788-93.
Source: PubMed

ABSTRACT The production and secretion of immunoreactive growth hormone-releasing factor (IR-GRF) by pheochromocytomas were examined immunohistochemically and immunochemically. GRF-immunoreactive (GRF-IR) cells were found, although sparsely, in 2 of 13 tumors (Cases 1 and 2), while somatostatin (SRIF)-IR cells and vasoactive intestinal peptide (VIP)-IR cells were found in nine and five tumors, respectively. Concentrations of tissue IR-GRF of 29.8 and 17.2 ng/g wet weight tissue, respectively, were found in two (Cases 1 and 2) of three tumors examined. These three tumors also contained IR-SRIF at 19.5-105.5 ng/g wet weight tissue and IR-VIP at 13.6-24.8 ng/g wet weight tissue. An increased plasma IR-GRF concentration (30.0 pg/ml) was found in a blood sample taken from the inferior vena cava near the adrenal tumor in Case 1. This is the first report that some pheochromocytomas produce GRF and secrete it into the blood circulation.

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Keywords

13 tumors
 
17.2 ng/g wet weight tissue
 
adrenal tumor
 
blood circulation
 
Cases 1
 
first report
 
GRF
 
GRF-immunoreactive
 
GRF-IR
 
immunochemically
 
immunoreactive growth hormone-releasing factor
 
increased plasma IR-GRF concentration
 
inferior vena cava
 
IR-GRF
 
secretion
 
sparsely
 
SRIF)-IR cells
 
tissue IR-GRF
 
vasoactive intestinal peptide
 

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