Article

A genetic analysis of type 2 (non-insulin-dependent) diabetes mellitus in Punjabi Sikhs and British Caucasoid patients.

Medical Unit, London Hospital, Whitechapel, UK.
Diabetic Medicine (Impact Factor: 3.06). 11/1987; 4(6):526-30. DOI: 10.1111/j.1464-5491.1987.tb00923.x
Source: PubMed

ABSTRACT A genetic analysis of diabetic and non-diabetic Punjabi Sikhs (n = 164) was made for markers of non-insulin-dependent diabetes mellitus using insulin receptor, insulin, and HLA-D alpha chain gene probes. Additionally British Caucasoids (n = 163) were studied using the insulin receptor probe. Insulin receptor gene restriction fragment length polymorphisms were defined using Southern blot techniques and the restriction enzyme Bgl II and BAm Hl. In Punjabi Sikhs and British Caucasoids neither of the restriction fragment length polymorphisms distinguished non-insulin-dependent diabetes mellitus subjects from controls. In the Sikhs no association with non-insulin-dependent diabetes mellitus was seen with the hypervariable region of the insulin gene or with HLA-DR/DQ/DX alpha chain restriction fragment length polymorphisms. We therefore conclude that despite the high prevalence of non-insulin-dependent diabetes mellitus in Asians we were unable to find any genetic markers for this disease using the available cloned gene probes.

0 Followers
 · 
76 Views
  • Source
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: SUMMARY T here is no single cause of non-insulin-de- pendent diabetes mellitus (NIDDM). More than 60 specific diseases have been associ- ated with the NIDDM phenotype, but these account for
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Incidence and prevalence of Type 2 Diabetes mellitus (T2DM) continue to rise in Indian populations. Despite known roles for obesity, sedentary lifestyles and diet, genetic predisposition accounts for significant risk. The identification of susceptibility loci for both monogenic and typical (oligogenic) diabetes have introduced novel genes, pathways and mechanisms of diabetes pathogenesis. Very little data is available on T2DM susceptibility loci in Asian Indian population. An extensive consortium based approach is required to identify the susceptibility locus and genes responsible for common form of familial diabetes in India. By defining the genetic susceptibility loci, such studies will eventually facilitate a direct, systematic exploration of the interactions of environmental factors, obesity, insulin resistance, and genetic predisposition in the pathogenesis of T2DM and prediabetic traits and also will open new pathways of exploration and therapy. This article is a systematic review of genetic epidemiology of adult onset Type 2 Diabetes in Asian Indian Population and related research initiatives in India and abroad.
    International Journal of Human Genetics 01/2006; 6(1):1-13. · 0.16 Impact Factor