Digest Journal of Nanomaterials and Biostructures 01/2008; 3:215-220.

ABSTRACT Centella asiatica is a herb used since ancient times in Ayurveda to improve cognitive functioning. The current study aimed at managing the cognitive decline in elderly with mild cognitive impairment (MCI) and other age related problems. MCI is a serious problem which may be converted into Alzheimer disease. Although the concept of MCI is based on the presence of specific cognitive deficits, several studies show that these subjects can develop depression, disruptive behavior (e.g agitation, aggression). The present study was conducted in sixty elderly subjects with written consent obtained, registered at the geriatric out patient clinic at S.S. Hospital, BHU aged 65 and above. The Diagnostic tools used in this study were Mini Mental State Examination, Activities of Daily Living, Instrumental Activities of Daily living and Yesavage Geriatric Depression scale. The Centella asiatica extract was prescribed in dosage of 500mg twice a day (1000 mg daily) for 6 months. A favorable improvement is observed in cognitive functioning, depression and other age related conditions like Hypertension, insomnia, loss of appetite, constipation etc.

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    ABSTRACT: Cognitive disorders can be associated with brain trauma, neurodegenerative disease or as a part of physiological aging. Aging in humans is generally associated with deterioration of cognitive performance and, in particular, learning and memory. Different therapeutic approaches are available to treat cognitive impairment during physiological aging and neurodegenerative or psychiatric disorders. Traditional herbal medicine and numerous plants, either directly as supplements or indirectly in the form of food, improve brain functions including memory and attention. More than a hundred herbal medicinal plants have been traditionally used for learning and memory improvement, but only a few have been tested in randomized clinical trials. Here, we will enumerate those medicinal plants that show positive effects on various cognitive functions in learning and memory clinical trials. Moreover, besides natural products that show promising effects in clinical trials, we briefly discuss medicinal plants that have promising experimental data or initial clinical data and might have potential to reach a clinical trial in the near future.
    Molecules 06/2012; 17(9):10503-39. DOI:10.3390/molecules170910503 · 2.10 Impact Factor
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    ABSTRACT: Background. SuperUlam is a proprietary blend of natural ingredients aimed at supporting brain health. We aimed to evaluate the effect of SuperUlam on attention and mood in healthy adults. Methods. Twenty healthy individuals aged 35-65 were enrolled in this randomized, double-blind, placebo-controlled, crossover study. Study duration was 3 weeks and consisted of 3 visits. Measurement of cognitive function included computer-based testing of reaction time, complex attention, working memory, sustained attention, and executive functioning. Mood testing was performed via the profile of mood states (POMS) survey and the Chalder fatigue scale. Results. Cognitive function testing demonstrated a significant improvement from baseline in executive functioning, cognitive flexibility, reaction time, and working memory in the product group only (P < 0.05). When comparing the study product to placebo, the data demonstrated a significant decrease in tension, depression, and anger (P < 0.05). There was no significant difference between the product and placebo in the other measures of mood, including vigor, fatigue, confusion, and total mood disturbance. No adverse events were reported. Conclusions. Supplementation with SuperUlam is safe to consume with potential benefits to cognitive function and mood.
    Evidence-based Complementary and Alternative Medicine 11/2013; 2013:238454. DOI:10.1155/2013/238454 · 2.18 Impact Factor
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    ABSTRACT: Traditional medicine plays an important role in the healthcare system of Vietnam. Vietnamese traditional medicine (VTM) is underpinned by the oriental philosophy and theory of healing. VTM is largely influenced by traditional Chinese medicine, but differs to a certain extent. VTM is largely not evidence-based from a clinical perspective but subclinical research data from the past decades support the traditional use of many herbal VTM drugs. For safe use, knowledge of the occurrence of adverse reactions and herb-drug interactions is necessary. The Vietnamese government supports further development of VTM in a scientific way and integration of VTM with Western medicine. This article first gives an overview of the general aspects of VTM (historical perspective, regulatory aspects, comparison with traditional Chinese medicine, philosophical background, the Vietnamese market situation, quality assurance and formulations), and subsequently focuses on its safe and effective use in Vietnamese clinical pharmacy and medical practice.
    Expert Review of Clinical Pharmacology 07/2012; 5(4):459-77. DOI:10.1586/ecp.12.34

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