Effect of Centella asiatica on mild cognitive impairment (MCI) and other common age-related clinical problems

Digest Journal of Nanomaterials and Biostructures 01/2008; 3(4):215-220.


Centella asiatica is a herb used since ancient times in Ayurveda to improve cognitive functioning. The current study aimed at managing the cognitive decline in elderly with mild cognitive impairment (MCI) and other age related problems. MCI is a serious problem which may be converted into Alzheimer disease. Although the concept of MCI is based on the presence of specific cognitive deficits, several studies show that these subjects can develop depression, disruptive behavior (e.g agitation, aggression). The present study was conducted in sixty elderly subjects with written consent obtained, registered at the geriatric out patient clinic at S.S. Hospital, BHU aged 65 and above. The Diagnostic tools used in this study were Mini Mental State Examination, Activities of Daily Living, Instrumental Activities of Daily living and Yesavage Geriatric Depression scale. The Centella asiatica extract was prescribed in dosage of 500mg twice a day (1000 mg daily) for 6 months. A favorable improvement is observed in cognitive functioning, depression and other age related conditions like Hypertension, insomnia, loss of appetite, constipation etc.

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    • "An extract of Centella asiatica was also shown to decrease A␤ plaque burden in a transgenic mouse model of AD, however the extraction method was not described, making it difficult to speculate which compounds may be responsible for that effect [22]. In addition to these effects, the cognitive enhancing action of water extracts of Centella asiatica has also been demonstrated in multiple animal models [23] [24] [25] and in limited human studies [26] [27] [28] [29]. "
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    ABSTRACT: The accumulation of amyloid-β (Aβ) is a hallmark of Alzheimer's disease and is known to result in neurotoxicity both in vivo and in vitro. We previously demonstrated that treatment with the water extract of Centella asiatica (CAW) improves learning and memory deficits in Tg2576 mice, an animal model of Aβ accumulation. However the active compounds in CAW remain unknown. Here we used two in vitro models of Aβ toxicity to confirm this neuroprotective effect and identify several active constituents of the CAW extract. CAW reduced Aβ-induced cell death and attenuated Aβ-induced changes in tau expression and phosphorylation in both the MC65 and SH-SY5Y neuroblastoma cell lines. We confirmed and quantified the presence of several mono- and dicaffeoylquinic acids (CQAs) in CAW using chromatographic separation coupled to mass spectrometry and ultraviolet spectroscopy. Multiple dicaffeoylquinic acids showed efficacy in protecting MC65 cells against Aβ-induced cytotoxicity. Isochlorogenic acid A and 1,5-dicaffeoylquinic acid were found to be the most abundant CQAs in CAW, and the most active in protecting MC65 cells from Aβ-induced cell death. Both compounds showed neuroprotective activity in MC65 and SH-SY5Y cells at concentrations comparable to their levels in CAW. Each compound not only mitigated Aβ-induced cell death, but was able to attenuate Aβ-induced alterations in tau expression and phosphorylation in both cell lines, as seen with CAW. These data suggest that CQAs are active neuroprotective components in CAW, and therefore are important markers for future studies on CAW standardization, bioavailability, and dosing.
    Journal of Alzheimer's disease: JAD 01/2014; 40(2). DOI:10.3233/JAD-131913 · 4.15 Impact Factor
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    • "Early clinical evidence suggests improvement in cognitive function associated with Centella asiatica [42]. More recently, an aqueous extract of Centella asiatica standardized to constituent tannic acids, as well as asiaticoside and asiatic acid, improved cognitive performance in healthy men and women [43, 44] and in elderly subjects with mild cognitive impairment [45, 46]. "
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    ABSTRACT: Background. SuperUlam is a proprietary blend of natural ingredients aimed at supporting brain health. We aimed to evaluate the effect of SuperUlam on attention and mood in healthy adults. Methods. Twenty healthy individuals aged 35-65 were enrolled in this randomized, double-blind, placebo-controlled, crossover study. Study duration was 3 weeks and consisted of 3 visits. Measurement of cognitive function included computer-based testing of reaction time, complex attention, working memory, sustained attention, and executive functioning. Mood testing was performed via the profile of mood states (POMS) survey and the Chalder fatigue scale. Results. Cognitive function testing demonstrated a significant improvement from baseline in executive functioning, cognitive flexibility, reaction time, and working memory in the product group only (P < 0.05). When comparing the study product to placebo, the data demonstrated a significant decrease in tension, depression, and anger (P < 0.05). There was no significant difference between the product and placebo in the other measures of mood, including vigor, fatigue, confusion, and total mood disturbance. No adverse events were reported. Conclusions. Supplementation with SuperUlam is safe to consume with potential benefits to cognitive function and mood.
    Evidence-based Complementary and Alternative Medicine 11/2013; 2013(2):238454. DOI:10.1155/2013/238454 · 1.88 Impact Factor
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    • "The cognitive performance was measured using Woodcock-Johnson Cognitive Abilities Test III (WJCAT III), and the extract was found to have a remarkably positive influence on all of the subjects. A recent clinical study consisting of 60 elderly subjects with average age of 65 with mild cognitive deficiency indicated that C. asiatica extract administered at 500 mg dose twice per day during 6 months led to a significant cognitive improvement according to Mini Mental State Examination (MMSE) scoring [88] "
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    ABSTRACT: This paper covers the studies relevant to neuroprotective activity of Centella asiatica (L.) Urban, also known as "Gotu Kola." The plant is native to the Southeast Asia and has been used traditionally as brain tonic in ayurvedic medicine. The neuroprotective effect of C. asiatica has been searched using the key words "Centella, Centella asiatica, gotu kola, Asiatic pennywort, neuroprotection, and memory" through the electronic databases including Sciencedirect, Web of Science, Scopus, Pubmed, and Google Scholar. According to the literature survey, C. asiatica (gotu kola) has been reported to have a comprehensive neuroprotection by different modes of action such as enzyme inhibition, prevention of amyloid plaque formation in Alzheimer's disease, dopamine neurotoxicity in Parkinson's disease, and decreasing oxidative stress. Therefore, C. asiatica could be suggested to be a desired phytopharmaceutical with neuroprotective effect emerged from traditional medicine.
    Evidence-based Complementary and Alternative Medicine 05/2012; 2012(2):946259. DOI:10.1155/2012/946259 · 1.88 Impact Factor
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