Article

EFFECT OF CENTELLA ASIATICA ON MILD COGNITIVE IMPAIRMENT (MCI) AND OTHER COMMON AGE-RELATED CLINICAL PROBLEMS

Digest Journal of Nanomaterials and Biostructures 01/2008; 3:215-220.

ABSTRACT Centella asiatica is a herb used since ancient times in Ayurveda to improve cognitive functioning. The current study aimed at managing the cognitive decline in elderly with mild cognitive impairment (MCI) and other age related problems. MCI is a serious problem which may be converted into Alzheimer disease. Although the concept of MCI is based on the presence of specific cognitive deficits, several studies show that these subjects can develop depression, disruptive behavior (e.g agitation, aggression). The present study was conducted in sixty elderly subjects with written consent obtained, registered at the geriatric out patient clinic at S.S. Hospital, BHU aged 65 and above. The Diagnostic tools used in this study were Mini Mental State Examination, Activities of Daily Living, Instrumental Activities of Daily living and Yesavage Geriatric Depression scale. The Centella asiatica extract was prescribed in dosage of 500mg twice a day (1000 mg daily) for 6 months. A favorable improvement is observed in cognitive functioning, depression and other age related conditions like Hypertension, insomnia, loss of appetite, constipation etc.

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