Platelet activation and secretion associated with emotional stress

Circulation (Impact Factor: 14.43). 07/1985; 71(6):1129-34. DOI: 10.1161/01.CIR.71.6.1129
Source: PubMed

ABSTRACT Platelets are believed to play a role in the pathogenesis of atherosclerosis and of the vascular obstruction that causes the acute complications of coronary artery disease. Since specific behavioral patterns appear to be related to the development of coronary artery disease and since emotional stress may predispose an individual to acute cardiovascular ischemia, it was hypothesized that platelet activation by catecholamines might be involved in these events. To study emotional stress, plasma samples were obtained from 61 senior medical residents immediately before they were to speak in public. There were significant increases in the plasma concentrations of the platelet-secreted proteins platelet factor 4 and beta-thromboglobulin and epinephrine and norepinephrine immediately before speaking, which demonstrates that platelet activation and secretion occur in association with this type of emotional stress. Four trials were carried out to study the mechanism for this observed platelet secretion: (1) phenoxybenzamine, (2) propranolol, (3) 650 mg aspirin, and (4) 80 mg aspirin were given several hours before the public speaking engagement. Neither phenoxybenzamine nor propranolol in doses that blocked the hemodynamic effects of alpha 1- and beta 1-adrenergic stimulation modified platelet secretion. Aspirin also did not block platelet secretion, which suggests that platelets were not being stimulated through a cyclooxygenase-dependent pathway. This study provides direct evidence of platelet secretion in vivo in association with emotional stress, and underscores the potential importance of platelet activation and secretion in the acute events that occur in patients with vascular disease.

1 Read
  • Source
    • "Downloaded by [] at 22:06 11 August 2014 The platelet counts observed in our study were higher in lambs from the H group. From a welfare point of view, it is difficult to explain the increase in platelets in the less-stressed lambs. Some studies indicate that platelets increase in humans when they feel emotionally stressed (Levine et al., 1985). However, Wallen (1997) concluded that platelet secretion seems to invariably increase with physical exercise, suggesting that responses of platelets to mental stress are highly variable between individuals and situations. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Postweaning management strategies that include an element of social enrichment may reduce weaning stress and improve welfare and productive performance. We analyzed the effect of postweaning handling strategies on welfare and production traits in lambs. After weaning, 36 lambs were assigned to 3 experimental groups with 12 lambs each (control [C], fattening with gentle human female contact [H], and fattening with 2 adult ewes [E]). The average daily gain (ADG) was estimated. Blood samples were taken, and infrared thermography was used to estimate stress variables. There were significant differences among treatments (in favor of alternative strategies) regarding production and stress variables (cortisol, glucose, and creatine kinase). The results suggest that the lambs handled gently during the fattening were less reactive and better able to modulate their physiological stress. The E group adapted better to acute stress than the C group but was less efficient in modulating chronic stress. Both treatments showed higher slaughter live weights and better ADGs compared with the control. The use of social enrichment at weaning, especially to establish a positive human-nonhuman animal bond, alleviates lamb weaning stress and improves welfare and performance.
    Journal of Applied Animal Welfare Science 08/2014; 18(1):1-15. DOI:10.1080/10888705.2014.941107 · 0.74 Impact Factor
  • Source
    • "It has been noted in previous studies that an increased sympathetic activity associated with emotional stress results in a higher level of epinephrine, which is accompanied by an increased platelet reactivity with unexplained arterial and/or venous thrombotic events.[9] "
    [Show abstract] [Hide abstract]
    ABSTRACT: The sticky platelet syndrome (SPS) is a congenital disorder characterized by platelet hyperaggregability to epinephrine and/or adenosine diphosphate; this predisposes affected individuals to acute myocardial infarction, ischemic optic neuropathy, recurrent venous thromboembolism, and transient ischemic cerebral attacks and strokes. Here, we describe an unusual case with recurrent cerebrovascular accidents due to SPS, in the presence of a patent foramen ovale (PFO). We report an unusual case of a 56-year-old female patient with a PFO, who suffered from recurrent strokes despite long-term medication with clopidogrel for SPS. The patient underwent successful transcatheter closure of the PFO, and, in addition, she has been placed on low-dose acetylsalicylic acid. After 18-month follow-up, she demonstrated an intact atrial septum without any vegetations on the percutaneous device until today. She has had no further thromboembolic events.
    Journal of cardiovascular disease research 04/2011; 2(1):68-70. DOI:10.4103/0975-3583.78600
  • Source
    • "Finally, acute emotional stress (Levine et al., 1985; Malkoff et al., 1993), phlebotomy procedure, and specimen handling (Gurney et al., 2002) can all affect platelet activation assays. However, all participants underwent exactly the same phlebotomy procedure, the quality of the procedure was repeatedly verified, and all specimens were handled with extreme care. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Depression is associated with increased morbidity and mortality in patients with coronary heart disease (CHD). Increased platelet activation has been proposed as a potential mechanism by which depression may lead to adverse cardiovascular outcomes. In this cross-sectional study, we measured platelet activation in 104 patients with stable CHD, including 58 with a current episode of major depression and 46 without past or current major depression. Participants were instructed not to take aspirin for 7 days prior to the study appointment. Platelet activation was measured by plasma concentrations of platelet factor 4 (PF4) and beta-thromboglobulin (beta-TG), and by 24-h urinary concentrations of 11-dehydro-thromboxane B(2) (TBXB2). We observed no differences in the mean levels of PF4, B-TG or TBXB2 in patients with and without major depression. Results were unchanged after adjustment for age, smoking, use of aspirin, and use of any psychotropic medication. We found no evidence of an association between major depression and platelet activation as measured by plasma concentrations of PF4 and beta-TG, or urinary TBXB2 in 104 outpatients with stable CHD. These findings do not support a role for platelet activation in the association between depression and cardiovascular disease among patients with stable CHD.
    Psychiatry Research 02/2010; 175(3):200-4. DOI:10.1016/j.psychres.2009.01.010 · 2.47 Impact Factor
Show more


1 Read
Available from