Article

Management of mediastinal compression due to bronchogenic carcinoma.

Acta radiologica. Oncology 01/1985; 24(3):233-5. DOI: 10.3109/02841868509134392
Source: PubMed

ABSTRACT Fifty-six cases of bronchogenic carcinoma with mediastinal compression were analyzed retrospectively. Microscopic confirmation was obtained in 23 patients and small cell carcinoma was most frequent. Radiation treatment gave complete remission in about 70 per cent when the total tumour dose exceeded 35 Gy fractionated during 3 weeks. Addition of cyclophosphamide marginally increased the remission rate to about 85 per cent. Total tumour doses of less than 35 Gy gave obviously poorer results. The response rate was highest in small cell carcinoma.

0 Bookmarks
 · 
50 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: The treatment of a superior vena caval obstruction associated with a mediastinal mass is a true radiotherapeutic emergency. The heralding signs and symptoms and the morbidity of the syndrome justify beginning therapy before a pathologic diagnosis is established. In a series of 19 patients with superior vena cava syndrome, there was an excellent response to an initial high-dose course of irradiation, consisting of 400 rads midplane for 3 days, then reduced to conventional daily fractionation. It is concluded that rapid high-dose irradiation in the treatment of a superior vena cava syndrome is safe and effective.
    Cancer 11/1976; 38(4):1577-80. · 5.20 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Chest radiotherapy was given to 23 patients with small cell carcinoma of the lung after development of progressive intrathoracic tumor on chemotherapeutic regimens. Treatment schedules were variable, with a median dose of 3,200 rad (32 Gy) in 10 fractions. Objective tumor regression within the radiation portal was observed in 12 patients (52%). Only 3/12 responders did not develop clinically detectable local tumor recurrence before death. Actuarial median time to local tumor progression was 2.5 months in responding and 3.5 months in nonresponding patients. Relapse of intrathoracic small cell carcinoma despite combination chemotherapy was not effectively treated by chest irradiation in the doses utilized. If sustained local palliation is required in this population, higher doses of radiation should be considered.
    Radiology 09/1979; 132(2):443-6. · 6.34 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A clinical trial of 2 methods of treating malignant superior vena caval obstruction is presented. Twenty-eight selected patients were allocated to treatment with radiation and nitrogen mustard or radiation alone according to a strictly administered randomization scheme. It appears that there is no apparent advantage to the use of nitrogen mustard prior to irradiation. It would appear that, in view of the side effects of nitrogen mustard, the use of the initially high daily dose radiation technique, combined with judicious use of diuretics, would be preferable.
    Cancer 10/1969; 24(3):447-51. · 5.20 Impact Factor

Full-text

Download
0 Downloads