Article
Benign neurogenic tumors of the oral cavity.
Oral and Maxillofacial Department, Apostle Paul's Accident Hospital, Kifissia, Athens Greece; 40 Papadiamantopoulou St. 157 71 Athens Greece
International Journal of Oral and Maxillofacial Surgery (impact factor:
1.51).
03/1987;
16(1):70-6.
DOI:10.1016/S0901-5027(87)80033-4
pp.70-6
Source: PubMed
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Citations (0)
- Cited In (2)
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Article: Neurofibromatosis type 1: a clinicopathological study of the orofacial manifestations in 6 pediatric patients.
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ABSTRACT: Neurofibromatosis type 1 (NF1) is a relatively frequent mucocutaneous syndrome, which is transmitted as an autosomal dominant trait or which may represent neomutation. It is characterized by a variety of clinical manifestations, including multiple neurofibromas that are associated with a high risk of sarcomatous transformation. The aim of this report was to elucidate the orofacial manifestations observed in 6 pediatric patients (between 4 and 15 years of age) diagnosed with NF1. Physical, clinical, radiological, histological, and immunohistochemical studies were performed. Orofacial lesions were observed in all studied patients, located either in the soft tissues (4 cases) or centrally in the jaws (2 cases). All cases showed facial asymmetry, one of them exhibiting marked facial hemihypertrophy. All cases with soft tissue involvement were plexiform neurofibromas, while the intraosseous cases were diagnosed as solitary neurofibromas. Knowledge of the variability of presentation of orofacial soft tissue and bone manifestations of NF1 in children is necessary for prompt diagnosis.Pediatric dentistry 24(6):575-80. · 1.02 Impact Factor -
Article: Solitary neurofibroma of the gingiva with prominent differentiation of Meissner bodies: a case report.
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ABSTRACT: Oral neurofibromas are peripheral nerve sheath tumors, similar to schwannomas. Histological variations in oral neurofibromas are relatively uncommon. Here, we present a case of unique variation in the observed characteristics of a neurofibroma, with no relation to neurofibromatosis type-1 or von Recklinghausen disease of the skin. The neurofibroma was observed in the right mandibular gingiva of a 32-year-old Japanese woman. Histologically, it differed from conventional neurofibromas in that the tumor was composed of a mixture of fine fibrillary collagen in sheets and/or cords of neoplastic Schwann cells containing numerous clusters of Meissner bodies. Histologically, these bodies were in contact with neoplastic Schwann cells. The Meissner bodies were immunopositive for S-100 protein, neuron-specific enolase, and vimentin, but were negative for calretinin. CD34-positive spindle cells were observed around the Meissner bodies. No recurrence or signs of other tumors have been observed in the patient for 5 years after tumor resection. To the best of our knowledge, no formal descriptions of sporadic, solitary neurofibromas containing numerous Meissner bodies occurring in the oral cavity are available in literature. We believe that an uncommon proliferation of Meissner bodies, as seen in the present case, may result from aberrant differentiation of neoplastic Schwann cells.Diagnostic Pathology 01/2010; 5:61. · 1.64 Impact Factor
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Keywords
benign neurogenic tumors
endoneurium
neurofibromatosis
Neurogenic tumors
neurolemmomal cells
oral cavity
reactive process
schwannoma derive
solitary
von Recklinghausen's disease