Article

Effect of flunixin meglumine on Escherichia coli heat-stable enterotoxin-induced diarrhea in calves

Department of Veterinary Large Animal Medicine and Surgery, Texas A&M University, College Station 77843.
American Journal of Veterinary Research (Impact Factor: 1.21). 09/1988; 49(8):1431-3.
Source: PubMed

ABSTRACT In a study to evaluate the effect of flunixin meglumine on secretory diarrhea, 11 calves were assigned to 3 groups: group 1 (n = 3) served as controls, group-2 calves (n = 4) were given 2.2 mg of flunixin meglumine/kg, IM at 7 AM and 3 PM, and group-3 calves (n = 4) were given 2.2 mg of flunixin meglumine/kg, IM at 7 AM, 11 AM, and 3 PM. All calves were given approximately 200 micrograms of heat-stable Escherichia coli enterotoxin (STa) orally at 8 AM. Mean cumulative fecal output for groups 1, 2, and 3 was 1,331.0 +/- 317.2 g, 1,544.3 +/- 154.4 g, and 785.5 +/- 276.5 g, respectively. There was a significant (P less than 0.05) reduction in mean fecal output in group-3 calves, compared with that in groups 1 and 2. Calves in group 2 tended to have a delay, but not a reduction, in their fecal output. At 12 hours, hemoconcentration was significantly (P less than 0.05) greater in group-1 calves than in group-2 or group-3 calves.

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    • "Non-steroidal anti-inflammatory drug therapy with meloxicam has proven effective in improving food intake and weight gain in diarrhoeic calves [38,39]. Flunixin meglumine showed some beneficial effect in experimental calves orally challenged with heat-stable Escherichia coli enterotoxin [40] and in calves with naturally acquired bloody diarrhoea, but not in calves without faecal blood [41]. "
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    • "A crucial step in the pathogenesis of ETEC is the binding of the secreted STa to its putative receptor on the apical surface of the intestinal epithelium (Dean & Isaacson, 1985; Roussel et al., 1988; Jaso-Friedmann et al., 1992; Butler & Clarke, 1994; Al-Majali et al., 2000b). In this study, we investigated the distribution of STa-receptor throughout the intestinal tracts of newborn kids. "
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    • "Upon binding its receptor, STa activates GC, which converts guanosine triphosphate to cyclic guanosine monophosphate (cGMP) [ 1525,261. Increases in intracellular cGMP inhibit the Na+/Cll cotransport system in the small intestinal villus enterocytes [2] [27]. "
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