The pursuit of intoxication: our 100 century-old romance with psychoactive substances.
Department of Psychiatry, University of Minnesota, Minneapolis 55455.The American Journal of Drug and Alcohol Abuse (Impact Factor: 1.47). 02/1988; 14(2):175-87. DOI: 10.3109/00952999809001545
AIDS patient care 08/1991; 5(4):168-171. DOI:10.1089/apc.1991.5.168
American Journal of Psychiatry 02/2014; 171(2):231-2. DOI:10.1176/appi.ajp.2013.13091242 · 14.72 Impact Factor
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ABSTRACT: Methamphetamine (METH) is a popular drug of abuse, readily synthesized in clandestine laboratories. Illicit synthesis results in various contaminants, one of which is a-benzyl-N-methylphenethylamine (BNMPA). This dissertation investigates the hypotheses that contaminants like BNMPA may contribute to the toxicity of METH and that detection of BNMPNmetabolites in biological fluids may be utilized as markers of illicit METH consumption. Based on metabolic studies of benzphetamine (a structurally similar compound), we predicted the four major metabolites of BNMPA to be N- demethyl-BNMPA, diphenyl-2-propanone, para-hydroxy-N-demethyl-BNMPA para-hydroxy-BNMPA, and diphenyl-2-propanol. We synthesized these compounds and developed a gas chromatography/mass spectrometry detection method. We confirmed these as true metabolites in humans following ingestion. para-Hydroxy-BNMPA and para-hydrnxy-N-demethyl-BNMPA (as conjugates) were the major metabolites detected.
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