Article

Further isolation of HIV strains in Palermo: some biological properties of the new isolates.

Istituto di Igiene G. D'Alessandro, Università degli Studi, Palermo, Italy.
Microbiologica 11/1988; 11(4):329-37. pp.329-37
Source: PubMed

ABSTRACT 21 HIV strains were isolated from peripheral mononuclear cells of 31 adult and pediatric patients with AIDS or ARC and 10 apparently healthy HIV seropositive individuals. Viral isolation rate was correlated to the clinical status of patients, being very high in patients with AIDS or ARC, and lower in apparently healthy individuals. 4 isolates were propagated in cultures of a T-cell continuous line (Molt 4) and their biological properties were compared. The capacity to establish a chronic infection on Molt 4 cells and the extent of cytopathic effect of the infected cultures varied among the different strains. Moreover, differences in endpoint titrations of the supernatants and variable effects on cell multiplication and viability of Molt 4 cells were also observed. Our results further substantiate the existence of a wide heterogeneity of HIV strains.

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Keywords

21 HIV strains
 
ARC
 
biological properties
 
cell multiplication
 
chronic infection
 
cultures
 
differences
 
healthy individuals
 
infected cultures varied
 
Molt 4
 
Molt 4 cells
 
patients
 
pediatric patients
 
T-cell continuous line
 
variable effects
 

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