Article

MICROALBUMINURIA ELEVATED IN PREDIABETIC& DIABETIC CAD PATIENTS FOLLOWING PCI

Journal of Diabetes 04/2009; 1:A228.

ABSTRACT Aim: To evaluate incidence of contrast induced nephropathy (CIN)
following Percutaneous intervention (PCI) by changes in serum creatinine
and involvement of microalbumin & urine microalbumin per gm creatinine
in diabetic and prediabetic patients. In India 30% of population have risk
factors of CAD, PCI and coronary angiogram remains the gold standard.
Iatrogenic renal function impairment from exposure to contrast media (CM)
is unclear. Study to observe effect on serum creatinine levels and
microalbumin in urine of CAD patients undergoing PCI having normal
renal function, and the association with age, diabetes, for effect of volume
of contrast media, to identify CIN & microalbuminuria is taken up with preprocedure
levels as control.
Method: 70 CAD patients having normal renal function selected for PCI,
39 prediabetic & diabetic, 21 normal, Pre- procedure blood & urine samples
taken as control, Using Hitachi 912 assays for microalbumin & creatine, an
absolute increase of 0.5 mg/dl serum creatinine, at 48 and72 hours
following exposure to CM as accepted definition of CIN is taken, urine
microalbumin per gm creatinine was calculated & contrast volume
measured.
Results: In this study, serum creatinine levels, urine microalbumin and
microalbumin per gm creatinine levels.showed risk of CIN 16.7%. In the
non diabetic microalbuminuria sample A B, C was 7.05±2.05,10.68±3.29,
and13.33±4.25 and in diabetics it was15.14±5.02, 30.01±9.77 and
52.72±8.22 significance 0.034*.
Conclusion: At risk for CIN is 16.7%. The relation between urine
microalbumin in diabetic and non diabetic was (p< 0.034) and
microalbumin per gm creatinine (p=0.049) Thus elevation post procedure is
significant.

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