In 28 unselected patients with hyperthyroidism, platelet count, platelet hematocrit, mean platelet volume, and platelet distribution width were measured at the time of presentation and again when the patients were euthyroid. On return to the euthyroid state, there were highly significant falls in the mean values of the mean platelet volume (16% decline, P less than 0.001) and the platelet hematocrit (16% decline, P less than 0.001) and a slight but highly significant increase in the mean value of the platelet distribution width (2% increase, P less than 0.01). A decline in mean platelet volume was observed in 24 of 28 patients (86%); three patients showed no change. There was no significant change in the mean value of the platelet count. The observed effects of thyrotoxicosis on platelets appeared to be largely independent of the well-known effects on erythrocytes and white blood cells. An increase in mean platelet volume is a regular feature of hyperthyroidism that has not previously been described.
[Show abstract][Hide abstract] ABSTRACT: Die Arbeit mißt das mittlere Plättchenvolumen (MPV) im Citratblut dialysepflichtiger Patienten und untersucht es mittels bivariater Korrelationsanalyse und multivariater linearer Regressionsanalyse auf signifikante Assoziationen zu den weiteren, klinischen und biochemischen Parametern. Hierbei wurde festgestellt, daß das MPV bei dialysepflichtigen Patienten nicht nur ein Marker für verschiedene Dialyseparameter ist, sondern auch ein eigenständiger Risikofaktor für vaskuläre Erkrankungen wie arterieller Hypertonie und koronaren Herzerkrankungen.
[Show abstract][Hide abstract] ABSTRACT: The abnormalities of erythrocytes, leucocytes, thrombocytes and coagulation that have been reported, particularly in more recent years, to be associated with hyperthyroidism are surveyed. Several areas are highlighted where further investigations could lead to clinically useful insights, improved information about the haematological processes involved or to a better understanding of thyroid hormone action.
Postgraduate Medical Journal 11/1988; 64(756):735-42. DOI:10.1136/pgmj.64.756.735 · 1.45 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Abnormalities that have been reported for platelet indices and function, coagulation factors and tests, and the fibrinolytic system in hypothyroidism are reviewed. These abnormalities, although usually of limited importance clinically, may occasionally lead to major bleeding episodes and to diagnostic confusion.
Postgraduate Medical Journal 05/1990; 66(774):280-4. DOI:10.1136/pgmj.66.774.280 · 1.45 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.