Mean platelet volume is increased in hyperthyroidism
ABSTRACT In 28 unselected patients with hyperthyroidism, platelet count, platelet hematocrit, mean platelet volume, and platelet distribution width were measured at the time of presentation and again when the patients were euthyroid. On return to the euthyroid state, there were highly significant falls in the mean values of the mean platelet volume (16% decline, P less than 0.001) and the platelet hematocrit (16% decline, P less than 0.001) and a slight but highly significant increase in the mean value of the platelet distribution width (2% increase, P less than 0.01). A decline in mean platelet volume was observed in 24 of 28 patients (86%); three patients showed no change. There was no significant change in the mean value of the platelet count. The observed effects of thyrotoxicosis on platelets appeared to be largely independent of the well-known effects on erythrocytes and white blood cells. An increase in mean platelet volume is a regular feature of hyperthyroidism that has not previously been described.
SourceAvailable from: Samuel Ricardo Comar[Show abstract] [Hide abstract]
ABSTRACT: The hematology analysers developed from the decade of 70, provided platelet volume parameters as the mean platelet volume, the platelet distribution width and the plateletcrit. Since these parameters had become available, some studies to define its utility and significance had been carried through, and although the increasing number of literatures that suggest the determination of these parameters can be useful in the diagnosis and treatment of hematologic disease beyond other pathological states, its use, on the part of health professionals, has been small. The low use of these indices in the practical doctor can have explanation in the difficulty to become critical evaluations of the clinical studies, since it requires familiarity with the possible changes of the platelet volume, provoked for devices, which occur in the processing of the samples in the clinical laboratories and the lack of knowledge of the physiological variation of the platelet size. A literature revision becomes necessary in order to add knowledge to understand the pathophysiological mechanisms of the alterations of platelet volume to assist the health professionals in the interpretation and in the clinical and laboratorial application of these parameters.
[Show abstract] [Hide abstract]
ABSTRACT: Data regarding the association between red cell distribution width (RDW) values and mortality in patients with stable coronary artery disease are scarce. We aimed to investigate the link between mortality and RDW in patients with stable coronary artery disease undergoing percutaneous coronary intervention (PCI). We analyzed 2550 consecutive patients with stable coronary artery disease who underwent PCI between 2007 and 2011 at our institution. The patients were divided into four groups according to RDW quartiles. The association between the RDW values and the outcomes was assessed using Cox proportional regression analysis after adjusting for clinical, echocardiographic, hemodynamic and laboratory data in the whole population and in subgroups stratified by gender, presence of diabetes, anemia or heart failure. In the entire population, there was a stepwise relationship between RDW intervals and comorbidities. Patients with the highest RDW values were older and more often burdened with diabetes, heart failure and chronic kidney disease. There was an almost 4-fold increase in mortality during an average of 2.5 years of follow-up between the group of patients with RDW values lower than 13.1% (25th percentile) and the group with RDW values higher than 14.1% (75th percentile), (4.3% vs. 17.1%, p < 0.0001). After adjusting for the covariates, RDW remained significantly associated with mortality in the whole cohort (HR-1.23 [95% CI (1.13-1.35), p < 0.0001]) and in the subgroups stratified by gender, age (over and under 75 years), presence of anemia, diabetes, heart failure and chronic kidney disease. Higher RDW values correspond to higher comorbidity burdens and higher mortality. RDW is an independent predictor of mortality in patients with stable coronary artery disease.BMC Cardiovascular Disorders 12/2013; 13(1):113. DOI:10.1186/1471-2261-13-113 · 1.50 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Abstract This study was performed to investigate the correlation between mean platelet volume, as an indicator of thrombocyte function, and placental grade classified by the Grannum scoring system. Placental sonographic images were graded according to the Grannum scoring system, and synchronous haemogram samples were taken from patients who attended foetal assessments during the second and third trimesters. A total of 75 patients were in their second trimester, and 40 patients were in their third trimester. The relation between week of pregnancy and placental Grannum score was significant (p < 0.001); i.e. placental Grannum score increased with gestational age. The association between Grannum score and mean platelet volume was analysed, including trimester and mean platelet volume, by linear regression analysis. The results indicated a distinct trimester-independent correlation between mean platelet volume and Grannum score (partial correlation coefficient = 0.455; p < 0.001). However, no correlation was observed between Grannum score and gravity (r = 0.87; p = 0.356), parity (r = 0.97; p = 0.302) or abortion (r = 0.011; p = 0.91). The correlation between mean platelet volume and placental calcification was investigated, and mean platelet volume in patients with a calcified placenta was 8.23 ± 1.14, whereas mean platelet volume in placentas with no calcification was 7.92 ± 1.18 (p = 0.233). Mean platelet volume was an independent indicator of Grannum score, which is an indicator of placental grade, in women in the second and third trimester of pregnancy. Assessing mean platelet volume during routine screening may identify functional placental disorders.Platelets 07/2013; DOI:10.3109/09537104.2013.807911 · 2.63 Impact Factor