Age and sex distribution of DSM-III personality cluster traits in a community population.
ABSTRACT DSM-III pathological personality cluster traits were measured on a community sample of 235 people. Traits in the schizoid cluster (schizoid, schizotypal, and paranoid) showed no change with age while traits in the dramatic cluster (antisocial, narcissistic, borderline, and histrionic) and to some extent the anxious cluster (avoidant, dependent, compulsive, and passive/aggressive) showed similar significant associations with age. This pattern was a reverse "J" shaped curve, with mean number of traits declining from younger to older groups and a slight upturn in the oldest age group (60 years plus). Women aged 31 to 40 years had a higher mean number of traits than their male counterparts, with a corresponding increase in impairment. The highest levels of personality traits in men were found at ages 18 to 30, while in women the 31 to 40 year group was highest.
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ABSTRACT: The present study examined the association between a measure of sociopathy and 5-HTTLPR genotype in a sample of individuals from Project MATCH, a multi-center alcohol treatment trial. 5-HTTLPR, an insertion-deletion polymorphism in SLC6A4, the gene encoding the serotonin transporter protein, results in functionally distinct long (L) and short (S) alleles. The S allele has been associated with a variety of psychiatric disorders and symptoms including alcohol dependence, but it is unknown whether 5-HTTLPR increases the risk for co-morbid sociopathy among those with alcohol dependence. Eight hundred sixty-two subjects diagnosed with alcohol dependence completed the California Psychological Inventory, a psychological assessment that includes a measure of socialization, which was used as a proxy measure of sociopathy. Subjects were genotyped for the insertion-deletion polymorphism, as well as a single nucleotide polymorphism (A→G) that is located in the inserted region. Regression analysis revealed that after controlling for age, which was negatively related to socialization score, 5-HTTLPR genotype interacted with sex to determine socialization score (P < 0.001). Males with the L'L' genotype (i.e. those homozygous for the L(A) allele) had lower socialization scores (i.e. greater sociopathy) than males who were carriers of the S' allele (P = 0.03). In contrast, women with the S'S' genotype had lower socialization scores than women with two L' alleles (P = 0.002) and tended to have lower Socialization Index of the California Psychological Inventory scores than women with one copy of the L' allele (P = 0.07). Among individuals with alcohol use disorders, the tri-allelic 5-HTTLPR polymorphism had opposite effects on socialization scores in men than women. The basis for this finding is unknown, but it may have implications for sub-typing alcoholics.Addiction Biology 02/2010; 16(1):124-32. DOI:10.1111/j.1369-1600.2009.00197.x · 5.93 Impact Factor
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ABSTRACT: To evaluate the role of personality in cocaine abuse, 59 adults meeting DSM-III criteria for cocaine abuse were compared to similar-aged non-cocaine alcohol abusers and community controls on a DSM-III measure of personality. Cocaine abusers were more likely than non-cocaine alcohol abusers to display narcissistic personality traits (Odds ratio 6.86, 95% CI = 4.52, 15.60). (Am J Public Health 1989; 79:891-892.American Journal of Public Health 08/1989; 79(7):891-2. DOI:10.2105/AJPH.79.7.891 · 4.23 Impact Factor
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ABSTRACT: A modified version of the revised Personality Diagnostic Questionnaire (PDQ-R), based on DSM-III-R personality disorders (PD), was completed by 74 psychiatric patients. A factor analysis of the scores for each of the PD (i.e. of the number of positive DSM-III-R criteria for each of the PD) yielded 3 factors that defined 3 PD clusters. These were similar to the 3 DMS-III-R PD clusters for 7 of the 11 PD categories. The 3-group solution of a cluster analysis of the patients (using their scores of positive criteria for each of the PD) did not reflect these factors; the main discriminating variable between the 3 groups of patients was the total number of positive PD criteria. It is suggested that, for the routine assessment of patients, the most important derivative of the DSM-III-R classification of PD is the total score of positive PD criteria.Acta Psychiatrica Scandinavica 01/1992; 84(6):555-60. DOI:10.1111/j.1600-0447.1991.tb03194.x · 5.55 Impact Factor