Nifedipine in patients with Raynaud's syndrome--effects on radial artery blood flow.
University Department of Surgery, University of Wales College of Medicine, Cardiff.European Heart Journal (Impact Factor: 15.2). 12/1987; 8 Suppl K:83-6. DOI: 10.1093/eurheartj/8.suppl_K.83
The acute effect of nifedipine on hand blood flow of 20 patients with Raynaud's phenomenon, treated in a double-blind, crossover study, is reported. Radial artery blood flow was found to correlate with the reciprocal of the pulsatility index. This simple Doppler technique gave an instantaneous record of the effect of cooling on hand blood flow. In patients with Raynaud's phenomenon, nifedipine prevents the reduction of hand blood flow that is induced by cooling in untreated patients.
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ABSTRACT: Low-flow perfusion of paced (5 Hz) rat heart Langendorff preparation with Tyrode solution for 60 min caused a reduction or disappearance of left ventricular pressure amplitude. After 60 min of low-flow perfusion myocardial concentrations of high energy phosphates, as well as the energy charged potential, were diminished while lactate accumulated. Infusion of alinidine into the perfusate at low-flow conditions, resulted in a mean concentration of 15.0 +/- 0.60 microM, and prevented the mechanical and biochemical changes of low-flow perfusion, thus indicating maintenance of aerobic metabolism under hypoxic conditions. These heart rate-independent cardioprotective effects of the "specific bradycardic" drug alinidine are discussed in light of the adenosine antagonistic actions of this compound which should prevent coronary steal.Archiv für Kreislaufforschung 01/1990; 85(1):71-7. DOI:10.1007/BF01907015 · 5.41 Impact Factor
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