Article

Intracranial transplantation of human hematopoietic cell lines in nude mice: a preclinical screening model for cytostatic drugs.

Anticancer research (impact factor: 1.73). 7(1):49-53. pp.49-53
Source: PubMed

ABSTRACT This study examines the suitability of the intracranial route of transplantation of human cell lines in nude mice for preclinical testing of cytostatic drugs. Tumours were generated by inoculation of human hematopoietic cell lines. Animals in which intramuscularly or intracranially transplanted human tumours developed were treated with cytostatic drugs. Three different cell line generated tumours (T-ALL L735, Hodgkin cell line L540 and Burkitt Lymphoma Line BJAB) were treated with four different drugs (CY, ADM, VCR, VP16). The data show a good correspondence between the results of treatment of intramuscularly and intracranially transplanted tumours. Thus intracranially transplanted tumour in nude mice are suitable for the testing of cytostatic drugs.

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Keywords

Burkitt Lymphoma Line BJAB
 
CY
 
cytostatic drugs
 
different cell line
 
Hodgkin cell line L540
 
human cell lines
 
human hematopoietic cell lines
 
human tumours
 
inoculation
 
intracranial route
 
intracranially
 
intramuscularly
 
nude mice
 
preclinical testing
 
study examines
 
transplantation
 
tumours
 

A Engert