Neuropsychological dysfunction in sleep apnea.
ABSTRACT To evaluate the effect of intermittent hypoxemia on neuropsychological functioning, neuropsychological tests were administered to 14 sleep apnea patients, a control group of 10 patients with other disorders of excessive somnolence, and another control group of 14 healthy volunteers. The sleep disorder groups were matched on two measures of sleepiness. It was found that sleep apnea patients performed significantly worse than both controls on 7 of 14 neuropsychological measures and on a rating of global neuropsychological impairment. The overall level of performance reflected only moderate impairment. Within the sleep apnea group, hypoxemia severity was significantly correlated with deficits on measures of motor and perceptual-organizational ability.
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ABSTRACT: Patients with obstructive sleep apnea (OSA) are likely to develop cognitive impairments, including problems with concentration, memory, and executive function. The etiology of these deficits is not fully resolved, although sleep fragmentation, excessive sleepiness, and hypoxemia appear to interact to produce neurologic consequences in patients with OSA. Disturbingly, a proportion of the cognitive dysfunction caused by hypoxic brain damage may be irreversible. Many patients with OSA will present in the primary care setting and may not know that they have a sleep disorder. Vigilance for the cognitive symptoms of OSA could assist in recognition by primary care physicians and aid in the prevention of lasting neuro-cognitive sequelae in this patient population.
Archives of Internal Medicine 10/1994; 154(19):2219. DOI:10.1001/archinte.1994.00420190121014 · 13.25 Impact Factor
Sleep Medicine 02/2015; DOI:10.1016/j.sleep.2015.01.017 · 3.10 Impact Factor