Alprazolam in the Treatment of Anticipatory and Acute Situational Anxiety in Children with Cancer

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Journal of the American Academy of Child & Adolescent Psychiatry (Impact Factor: 7.26). 08/1987; 26(4):532-5. DOI: 10.1097/00004583-198707000-00012
Source: PubMed


A population of childhood cancer patients who undergo scheduled, periodic, stressful events such as bone marrow aspirations and spinal taps was chosen as a model for the investigation of the use of alprazolam in the treatment of anticipatory and acute situational anxiety in children. An open-label dose-ranging study was completed on 13 children. Because this was an early trial of a drug not approved for use in children, doses were low. Nonetheless, safe efficacious use of alprazolam was demonstrated and indicates that antianxiety agents may have a useful purpose for brief intervention situations in children.

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