Alterations in cerebrospinal fluid concentrations of somatostatinlike immunore-activity in neuropsychiatric disorders

Archives of General Psychiatry (Impact Factor: 13.75). 01/1987; 43(12):1148-51.
Source: PubMed

ABSTRACT The concentration of somatostatinlike immunoreactivity in cerebrospinal fluid (CSF) from normal, healthy volunteers (n = 10) and patients with DSM-III diagnoses of major depression (n = 17), schizophrenia (n = 11), or dementia (n = 29) was measured by a sensitive and specific radioimmunoassay. Statistically significant decreases in CSF concentrations of somatostatinlike immunoreactivity were seen in all three patient populations when compared with controls. These findings confirm previous reports of decreased concentrations of somatostatinlike immunoreactivity in the CSF of patients with depression and dementia and extend this observation to patients with schizophrenia as well. These findings are concordant with the view that reductions in somatostatinlike immunoreactivity concentrations are associated with diseases in which cognitive function is disturbed.

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Available from: Charles B Nemeroff, Aug 27, 2015
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    • "A limited number of studies have linked depression or the effect of antidepressants with the activity of the SRIF system. Cerebrospinal fluid (CSF) SRIF-like immunoreactivity (SRIF-LI) levels have been shown consistently to be reduced in patients with major depression and to be normalized during recovery (Bissette et al, 1986; Rubinow, 1986; Pazzaglia et al, 1995). Interestingly, Gerner and Yamada (1982) reported significant reductions in SRIF levels in the CSF of depressed patients, whereas increased levels were observed in patients with mania, a finding that was not observed by others (Rubinow et al, 1983). "
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    • "However, the specificity of this finding is somewhat weakened by the intermediate mea~ values of the CSF peptides in the delirium subgroup (Table 3). It is also difficult to explain why CSF SRIF appeared to be uniformly normal in this population, in contrast to other findings (Bissette et al 1986). One possibility is the longer duration of illness in this study, although the relationship between dementia and central SRIF metabolism is far from clear (Sagar et al 1984; WaUin et al 1991). "
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