Article

Chang S, Zimmerman NJ, Iwamoto T, et al.. Experimental vitreous replacement with perfluorotributylamine

American Journal of Ophthalmology (Impact Factor: 4.02). 02/1987; 103(1):29-37. DOI: 10.1016/S0002-9394(14)74165-0
Source: PubMed

ABSTRACT Perfluorotributylamine, a liquid fluorochemical used in artificial blood substitution, was evaluated for potential application as a vitreous substitute having heavier density than saline. It was injected into the vitreous of 38 rabbit eyes after mechanical vitrectomy or gas compression of the vitreous with perfluoropropane. The eyes were observed for periods of up to five months. Clinically the liquid occupied the lower vitreous space but gradually dispersed into smaller fluorochemical droplets. In the upper vitreous clusters of cells appeared within three to four weeks which precipitated on the posterior lens surface and in the cortical vitreous. In eyes with experimental retinal detachment perfluorotributylamine had physical properties which provided mechanical retinal tamponade. Its interfacial tension prevented passage through iatrogenic retinal breaks. Histopathologic findings showed irregularly shaped defects in the outer segment disks as early as two days after vitreous replacement. These changes appeared to reverse if perfluorotributylamine was removed after two days. The cellular response in the vitreous consisted primarily of monocyte-derived macrophages capable of ingesting fluorochemical (foam cells).

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    • "These are fully fluorinated alkane compounds with a high specific gravity. However, these compounds turned out to be unsuitable long-term internal tamponade because of the mechanical damage on the retina and the tendency for droplet dispersion [7] [8] [9]. Presently, these compounds are widely used as intraoperative tools, but not as vitreous sub- stitutes. "
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    BioMed Research International 07/2014; 2014:574825. DOI:10.1155/2014/574825 · 2.71 Impact Factor
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    • "Studies in rabbit, guinea-pig, mouse, owl monkey, cat and tiger salamander show that if the potassium siphoning into the vitreous does not work, the subretinal space might be used as an alternative sink (Newman 1987; Newman & Reichenbach 1996). Long-lasting potassium accumulation causes subsequent retinal degeneration; in our study, however, only inner retinal degeneration was encountered, possibly because the outer retinal layers are still protected by means of alternative siphoning mentioned above (Chang et al. 1987; Stolba et al. 1997). "
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