Pathology of the heart in drowning
Although ventricular fibrillation is a frequent cause of death in nearly drowned animals, the heart itself has never been studied in this condition. Working with a rabbit model, we have simulated the "near drowning" state and found that the heart undergoes some pathologic changes, including myocyte hypercontraction and hypereosinophilia. These changes may well account for the variety of arrhythmic disturbances that have been observed.
Available from: Steven B Karch
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ABSTRACT: In order to study the initial pathological changes that occur in drowning, the authors developed an experimental model that closely simulates the actual changes in the nearly drowned patient. Adult male rabbits were anesthetized and intubated, and 6 ml/kg of fresh or salt water was instilled directly into the endotracheal tube. The animals were killed after 29 minutes, and the heart and lungs were then examined microscopically. The authors found that in the first 30 minutes, the brunt of the damage is borne by the vascular endothelium and not the alveolar cells.
American Journal of Emergency Medicine 02/1986; 4(1):4-9. DOI:10.1016/0735-6757(86)90240-8 · 1.27 Impact Factor
Human Pathlogy 02/1986; 17(1):9-13. DOI:10.1016/S0046-8177(86)80150-2 · 2.77 Impact Factor
American Journal of Emergency Medicine 04/1986; 4(2):189-92. DOI:10.1016/0735-6757(86)90175-0 · 1.27 Impact Factor
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