Pathology of the heart in drowning
Archives of pathology & laboratory medicine (Impact Factor: 2.84). 03/1985; 109(2):176-8.
Although ventricular fibrillation is a frequent cause of death in nearly drowned animals, the heart itself has never been studied in this condition. Working with a rabbit model, we have simulated the "near drowning" state and found that the heart undergoes some pathologic changes, including myocyte hypercontraction and hypereosinophilia. These changes may well account for the variety of arrhythmic disturbances that have been observed.
- American Journal of Emergency Medicine 04/1986; 4(2):189-92. DOI:10.1016/0735-6757(86)90175-0 · 1.27 Impact Factor
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ABSTRACT: Systemic and pulmonary hemodynamics were studied in two groups of Chacma baboons following the induction of brain death. Group A was a control group of 11 animals who underwent brain death. They showed significant increments of mean systemic arterial, left atrial, and pulmonary arterial pressures; of systemic vascular resistance, heart rate, and pulmonary artery blood flow; and a reduction in aortic blood flow during the induction of brain death. As a result of increased sympathetic nervous system activity, areas of myocardial cell necrosis occurred in 73% of the animals and pulmonary edema in 36%. Group B consisted of five animals that were pretreated with verapamil hydrochloride infused over a period of 30 minutes prior to the induction of brain death (mean dosage, 0.26 mg/kg). Except for a rise in heart rate, no significant changes occurred in systemic or pulmonary hemodynamics, and no myocardial or pulmonary histopathological changes were seen. These findings would indicate that verapamil hydrochloride prevents both the peripheral and central hemodynamic changes that result from increased sympathetic activity associated with the induction of brain death, and thus prevents myocardial structural damage, which may be associated with increased calcium uptake by the myocyte.American Journal of Emergency Medicine 02/1987; 5(1):11-8. DOI:10.1016/0735-6757(87)90282-8 · 1.27 Impact Factor
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ABSTRACT: The incidence of myofibrillar degeneration (MFD) was studied in the following different forensic-pathological diagnostic groups of 25 cases each: acute morphine intoxication, acute carbon monoxide intoxication, hanging, strangulation by hand/ligature, drowning, acute hemorrhagic shock, lethal acute brain injury, explainable death of babies or infants and sudden infant death syndrome, together with 18 cases of intoxication with various drugs. The MFD was demonstrated by the Luxol-fast-blue reaction, with two types of phenomena being differentiated, namely cross-band lesions and diffuse staining. All diagnostic groups included cases of MFD of differing degrees. Cross-band lesions were observed in practically all cases of hanging, strangulation and acute hemorrhagic shock. Diffuse stain was noted particularly in cases of drowning and acute brain injury. The diagnostic significance is discussed.Forensic Science International 01/1991; 48(2):163-73. DOI:10.1016/0379-0738(90)90109-C · 2.14 Impact Factor
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