Unusual Ph translocations in CML: four new cases.

Istituto Scientifico di Medicina Interna, Cattedra di Ematologia, Università di Genova, Genova, Italy.; Istituto Scientifico di Medicina Interna, Cattedra di Biologia Generale, Università di Genova, Genova, Italy.; Istituto Scientifico di Medicina Interna, Cattedra di Terapia Medica, Università di Genova, Genova, Italy.
Cancer Genetics and Cytogenetics (Impact Factor: 1.93). 03/1985; 15(3-4):199-207. DOI: 10.1016/0165-4608(85)90163-3
Source: PubMed

ABSTRACT Four variants of the Ph chromosome translocation in chronic myelogenous leukemia (CML) patients are described. Two had an unusual simple translocation involving chromosomes #7 and #17. In two cases, the translocation, aside from involving #9 and #22, involved a third chromosome, chromosome #6 and chromosome #11, respectively. Three cases showed also karyotypic evolution during the blastic phase of the disease: in two cases, a new reciprocal translocation was found that involved a chromosome #9 at band q34. The clinical and cytogenetic significance of these results is briefly discussed.

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