Kidney disorders and hematotoxicity from organic solvent exposure.

Scandinavian Journal of Work, Environment & Health (Impact Factor: 3.1). 02/1985; 11 Suppl 1:83-90.
Source: PubMed

ABSTRACT Short-term exposure to certain solvents, such as several halogenated hydrocarbons, petroleum distillates, ethylene glycol, ethylene glycol ethers, and diethylene glycol, may cause renal tubular necrosis. Tubular lesions with metabolic acidosis have been reported in addicts inhaling solvent vapor (eg, toluene). A Goodpasture's syndrome may be induced by acute or subacute exposure to solvents, but its incidence is rare. No adequate proof is yet available that repeated exposure to nonsubstituted organic solvents may lead to the development of different types of chronic glomerulonephritis, but the available epidemiologic data are suggestive of the existence of such an association. Only a few solvents have been reported to act on the hematopoietic system of humans. The hematotoxicity (aplastic anemia, leukemia) of benzene is well established. Some ethylene glycol ethers are also toxic to bone marrow.

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    • "ing a tubular necrosis , a life threatening situation characterized by oliguria and azotemia ( Sato et al . , 1988 ) . A study carried out by Taverner et al . ( 1988 ) showed that acute exposure to organic solvents caused reversible acute interstitial nephritis . A Goodpasture ' s syndrome may be induced by acute or subacute exposure to solvents ( Lauwerys et al . , 1985 ) . Renal tubular acidosis has been associated with toluene or toluene - containing paint sniffing ( Taher et al . , 1974 ) . Toluene sniffing has been implicated in the formation of renal stones ( Kroege et al . , 1980 ) , protei - nuria ( Streicher et al . , 1981 ) , and hepato - renal damage ( O ' Brien et al . , 1971 ) . Some studie"
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