Kidney disorders and hematotoxicity from organic solvent exposure.

Scandinavian Journal of Work, Environment & Health (Impact Factor: 3.1). 02/1985; 11 Suppl 1:83-90.
Source: PubMed

ABSTRACT Short-term exposure to certain solvents, such as several halogenated hydrocarbons, petroleum distillates, ethylene glycol, ethylene glycol ethers, and diethylene glycol, may cause renal tubular necrosis. Tubular lesions with metabolic acidosis have been reported in addicts inhaling solvent vapor (eg, toluene). A Goodpasture's syndrome may be induced by acute or subacute exposure to solvents, but its incidence is rare. No adequate proof is yet available that repeated exposure to nonsubstituted organic solvents may lead to the development of different types of chronic glomerulonephritis, but the available epidemiologic data are suggestive of the existence of such an association. Only a few solvents have been reported to act on the hematopoietic system of humans. The hematotoxicity (aplastic anemia, leukemia) of benzene is well established. Some ethylene glycol ethers are also toxic to bone marrow.

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Objective Benzene, as a volatile organic compound, is known as one of the main air pollutants in the environment. The aim of this review is to summarize all available evidences on non-cancerous health effects of benzene providing an overview of possible association of exposure to benzene with human chronic diseases, specially, in those regions of the world where benzene concentration is being poorly monitored. Methodology A bibliographic search of scientific databases including PubMed, Google Scholar, and Scirus was conducted with key words of “benzene toxic health effects”, “environmental volatile organic compounds”, “diabetes mellitus and environmental pollutants”, “breast cancer and environmental pollution”, “prevalence of lung cancer”, and “diabetes prevalence”. More than 300 peer reviewed papers were examined. Experimental and epidemiologic studies reporting health effects of benzene and volatile organic compounds were included in the study. Results Epidemiologic and experimental studies suggest that benzene exposure can lead to numerous non-cancerous health effects associated with functional aberration of vital systems in the body like reproductive, immune, nervous, endocrine, cardiovascular, and respiratory. Conclusion Chronic diseases have become a health burden of global dimension with special emphasis in regions with poor monitoring over contents of benzene in petrochemicals. Benzene is a well known carcinogen of blood and its components, but the concern of benzene exposure is more than carcinogenicity of blood components and should be evaluated in both epidemiologic and experimental studies. Aspect of interactions and mechanism of toxicity in relation to human general health problems especially endocrine disturbances with particular reference to diabetes, breast and lung cancers should be followed up.
    Toxicology and Applied Pharmacology 04/2014; 276(2). DOI:10.1016/j.taap.2014.02.012 · 3.63 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: It has been suggested that exposure to organic solvents may have a role in the impairment of kidney function that may progress to kidney failure. However, this has never been evaluated with an appropriate analytical study of the kidney functions of those people who are chronically exposed to these chemicals. This study was designed to measure the kid-ney function of car painters in the city of Makkah, Saudi Arabia. Fifty workers were selected at random for this study and compared to thirty male medical students who were taken as a control group. Blood samples were collected for the analysis of kidney function. The levels of blood urea nitrogen (BUN), creatinine, and uric acid were scientifically high-er in the tested group compared to the control group. In addition to this, the levels of these parameters were signifi-cantly higher in the serum of car painters who worked in this industry for more than ten years compared to painters who worked for less than ten years. Moreover, the number of car painters who were not using protective gloves and masks during working hours were 43 and the number of car painters who visited specialized clinics because of kidney problems were 45 of the 50 tested volunteers. These findings support the hypothesized association of solvent exposure with the development of chronic renal failure. They should prompt clinicians to give greater attention to patients' oc-cupational exposures. Routine monitoring of kidney functions and the use of protective materials are of greater impor-tance to minimize the occupational diseases caused by organic solvents.
    Journal of Environmental Protection 01/2011; 02(05). DOI:10.4236/jep.2011.25061
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: This paper, a discussion of “Psychosocial Characteristics and Their Links with Inhalants: A Research Agenda” by Oetting and Webb, commends the comprehensive literature review and notes that available literature consistently finds the same correlates to inhalant use. It suggests that this results from researcher's preconceptions about inhalant use reflected in questions asked, concepts implicit in those questions, the way answers are elicited, and the interpretation of responses.
    Substance Use &amp Misuse 01/1997; 32(12-13):1853-1858. DOI:10.3109/10826089709035593 · 1.23 Impact Factor