Acute Hepatitis B Virus Infection: Relation of Age to the Clinical Expression of Disease and Subsequent Development of the Carrier State

The Journal of Infectious Diseases (Impact Factor: 6). 05/1985; 151(4):599-603. DOI: 10.1093/infdis/151.4.599
Source: PubMed

ABSTRACT Yupik Eskimos of southwestern Alaska have the highest known prevalence of hepatitis B virus infection of any general population in the United States. Prospective serological surveys of 1,280 seronegative Yupik Eskimos, performed between 1971 and 1976, identified 189 (14.8%) who developed serological evidence of hepatitis B virus infection. Twenty-six (13.8%) developed clinical hepatitis during the interval when seroconversion occurred. The proportion of patients with clinically apparent hepatitis increased with age (P less than .01), ranging from 9.5% of infections in patients who were four years of age or less to 33.3% of infections in patients who were 30 years of age or older. Twenty-five (13.3%) of the 188 individuals who were studied became chronic carriers of hepatitis B surface antigen. The risk of becoming a carrier was inversely related to the age of the patient at the time of infection (P = .02). Among patients who were four years of age or less when infected, 28.8% became chronic carriers of hepatitis B, as compared with 7.7% of those who were 30 years of age or older.

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    • "In highly endemic areas the epidemiology of HBV exhibits two main features: a low average age at infection and a high prevalence of chronic carriers. According to numerous works (see for instance [5] [10] [18] [20] [28] and the references therein) there is a rapid decline in the probability of developing the chronic carrier stage of the disease with respect to the age at infection. According Edmunds et al [10], approximatively 90% of children of less than 5 years old will become carriers if infected while about 10% of adults will become carriers if infected. "
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    ABSTRACT: In this manuscript we consider an age structured epidemic system modelling the dynamics of transmission of Hepatitis B virus. Our model takes into account age specific differential susceptibility as well as two classes of infected individuals: the chronic carriers and the acute infected human. Based on the low infectivity of chronic carriers, we study the asymptotic behaviour of the system and, under some suitable assumptions, we prove the global stability of the endemic equilibrium point using perturbation arguments. (PhD work at University of Ngaounderen, supervised by Pr Békollè D. and Dr Houpa D. D. E.)
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    • "The clinical manifestations and natural history of HBV infection vary with age. Clinical acute hepatitis B is more frequent in adults than children, and the probability of becoming a chronic carrier of hepatitis B is greater in children than adults: 80–90% of people perinatally infected compared to <5% of infections occurring in adults [24]. People with chronic hepatitis B have a 15% to 25% risk of dying prematurely from HBV related complications [25]. "
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    ABSTRACT: Background. Hepatitis B virus (HBV) is a potentially life-threating infection and a well-recognized occupational hazard for health-care workers including medical students. Methods. A cross-sectional study was conducted at Syrian Private University (SPU), Faculty of Medicine, to assess the knowledge and awareness about hepatitis B, the status of hepatitis B vaccination, and the reasons for not getting vaccinated among the first- and the fifth-year medical students. Results. The present study demonstrates surprising results and raises issues about the high number of medical students that are not vaccinated or not sure about their vaccination status, which puts them at a higher risk of being infected in the future. Another important issue is the medical students’ overall knowledge about this life-threating infection. The students have not been totally educated about the gravity of the situation which requires the need of further HBV education. It is highly recommended that SPU provides the HBV vaccine to all nonvaccinated students attending the faculty of medicine at no cost to encourage them to take the HBV vaccine and to reform some of its educational curriculum to effectively limit the hazardous effects of this disease and elaborate on the serious health consequences of HBV
    Hepatitis research and treatment 11/2014; 2014(2014). DOI:10.1155/2014/131920
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    • "Chronic infection is defined by the presence of HBsAg for more than 6 months. Without immunization, up to 90% of infants born to mothers who are positive for HBsAg and HBeAg, become chronic carriers [17] [46] [62]. Hepatitis C virus is a single-stranded RNA virus, it is transmitted also through infected blood, sexually and vertically [21] [47] [73]. "
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    ABSTRACT: This study was carried out to determine sero-prevalence of hepatitis B and hepatitis C virus co-infection among pregnant women. Viral hepatitis during pregnancy is associated with high risk of maternal complications; infections with Hepatitis B virus (HBV) or the Hepatitis C virus (HCV) are public health problems. Worldwide, there are about 350 million HBV carriers and 130 to 170 million people infected with HCV. The presence of HBV and HCV was determined using third-generation enzyme immunoassay (EIA), reactive samples were further confirmed using enzyme linked immune sorbent assay (ELISA) (Bio-Rad, France). Age group 26-30 and 31-35 had highest frequency of 240 (36.98%) and 206 (31.74%) respectively in HBV and HCV. Sero prevalence of HBV and HCV were 44 (6.78%) and 9 (1.39%) respectively. Prevalence of HBV and HCV co-infection was 1 (0.15%) in age group 31-35. Proper management of maternal hepatitis during the prenatal phase ensures better outcomes in the infant, therefore screening of pregnant women for hepatitis B and C virus are necessary in order to identify those neonates at risk of transmission.
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