Article

Long-Term Prognosis After Myocardial Infarction in Men with Diabetes

Diabetes (Impact Factor: 8.47). 09/1985; 34(8):787-92. DOI: 10.2337/diab.34.8.787
Source: PubMed

ABSTRACT Men (1306) who survived a first myocardial infarction (MI) were studied. The mean follow-up time was 6.5 yr, and at the end of the follow-up period survival status was known for all patients. By the time of the MI the prevalence of diabetes was 5.6%. Patients with and without diabetes were compared. There were no differences in the estimated primary or secondary risk. The cumulative survival rate 1, 2, and 5 yr after the MI was 82, 78, and 58% among the diabetic subjects compared with 94, 92, and 82% among the nondiabetic subjects (P less than 0.001). The difference remained even after allowance for age and estimated secondary risk in a multivariate regression analysis. There were no differences in mortality rates among patients with type I diabetes compared with type II diabetes, nor among patients treated with diet alone, sulfonylurea, or insulin, but the numbers were small. The cumulative rate of reinfarctions after 1, 2, and 5 yr was 18, 28, and 46% in diabetic subjects and 12, 17, and 27% in nondiabetic subjects (P = 0.004). A history of diabetes was an independent secondary risk factor among male survivors of a first MI with respect to deaths and reinfarctions.

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    • "However, the management of acute coronary syndromes (ACS) does not differ for patients with diabetes versus without diabetes [9] [10]. The poor prognosis associated with diabetes after acute myocardial infarction (AMI) has been observed in some studies in spite of adjustment for age [11] [12], sex [13], "
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    ABSTRACT: We describe the baseline characteristics, management, and in-hospital outcomes of patients in the United Arab Emirates (UAE) with DM admitted with an acute coronary syndrome (ACS) and assess the influence of DM on in-hospital mortality. Data was analyzed from 1697 patients admitted to various hospitals in the UAE with a diagnosis of ACS in 2007 as part of the 1st Gulf RACE (Registry of Acute Coronary Events). Of 1697 patients enrolled, 668 (39.4%) were diabetics. Compared to patients without DM, diabetic patients were more likely to have a past history of coronary artery disease (49.1% versus 30.1%, P < 0.001), hypertension (67.2% versus 36%, P < 0.001), and prior revascularization (21% versus 11.4%, P < 0.001). They experienced more in-hospital recurrent ischemia (8.5% versus 5.1%; P = 0.004) and heart failure (20% versus 10%; P < 0.001). The mortality rate was 2.7% for diabetics and 1.6% for nondiabetics (P = 0.105). After age adjustment, in-hospital mortality increased by 3.5% per year of age (P = 0.016). This mortality was significantly higher in females than in males (P = 0.04). ACS patients with DM have different clinical characteristics and appear to have poorer outcomes.
    The Scientific World Journal 06/2012; 2012:698597. DOI:10.1100/2012/698597 · 1.73 Impact Factor
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    • "For example, heart failure is twice as common in patients with type 2 diabetes [8] compared with those without type 2 diabetes. Thus, the short term mortality rate of a patient with diabetes is reported to be twice that in those without diabetes [9,10] and patients with diabetes have reduced long term survival [2,11]. The relative risk of a primary MI is more common among women with type 2 diabetes than among men [12] However, there are currently few population-based estimates of the probability of survival following an AMI for people with diabetes compared with those without diabetes [2,13] and none look at time to re-infarction. "
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    BMC Public Health 06/2010; 10(1):338. DOI:10.1186/1471-2458-10-338 · 2.32 Impact Factor
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    • "In particular, the incidence of diabetes itself is growing at a rate of 6% annually (Partamian and Bradley, 1965; Kopelman and Hitman, 1998; Kopelman, 2000). This is disconcerting because diabetes is associated with a high incidence of complications, including heart disease and stroke (Kannel and McGee, 1979; Gwilt et al., 1985; Ulvenstam et al., 1985; Ingelsson et al., 2005). "
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