Seroepidemiological survey of chlamydial genital infections in Khartoum, Sudan.

Genitourinary medicine 09/1985; 61(4):261-3. DOI: 10.1136/sti.61.4.261
Source: PubMed

ABSTRACT A total of 494 patients (90 men and 404 women) attending a sexually transmitted diseases (STDs) clinic in Khartoum, Sudan, were studied to assess the prevalence of chlamydial genital infections. Antibodies to Chlamydia trachomatis serotypes D to K were found in four (4.4%) men and 42 (10.4%) women, and 10 (2.5%) women had antibodies to serotypes A to C.

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    ABSTRACT: Cervical secretion from women with and without symptoms and signs of genital infection were analysed for their ability to inhibit inclusion formation of Chlamydia trachomatis in McCoy cell cultures. Of 173 cervical samples, 115 (66 per cent) had antichlamydial activity. The inhibition was concentration-dependent and the inhibitory factor had a molecular weight of < 10 000 Da and was heat labile. C. trachomatis was isolated by culture from six (3 per cent) of the 173 women. Those who were culture-positive for C. trachomatis had higher levels of antichlamydial activity than other age matched women. There was no relation between the antichlamydial activity and the antichlamydial antibody titre either in cervical secretion or in sera, as measured by micro-immunofluorescence tests and an enzyme-linked immunosorbent assay.
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    ABSTRACT: The serology of various infections often caused by Chlamydia trachomatis including complications such as pelvic inflammatory disease (PID) and infertility was investigated comprehensively among diverse patient groups in a developing country using initially an indirect immunofluorescent antibody test (IFA). Any positives detected were further examined by a micro-immunofluorescence (MIF) method for the presence of type specific anti-chlamydial IgG/IgM antibodies. Conventional cell culture was carried out concurrently to compare culture results with serologic results. Among 416 patients (107 males and 309 females) C. trachomatis D-K antibodies to IgG were identified in 87 (20.9%) and to type specific IgM were identified in 11(2.6%) patients. Cell culture identified C. trachomatis in 60 patients (14.4%). C. trachomatis IgG antibodies were detectable in 6.4% of chlamydia culture negative patients.
    International Journal of Gynecology & Obstetrics 01/1989; 27(3):377-80. DOI:10.1016/0020-7292(88)90116-6 · 1.56 Impact Factor
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    ABSTRACT: To assess whether the extent of female genital mutilation (FGM) influences the risk of acquiring sexually transmitted infections (STIs). Hospital-based case-control study. Two obstetric/gynaecological outpatient clinics in Khartoum, Sudan, 2003-2004. A total of 222 women aged 17-35 years coming to antenatal and gynaecological clinics. Women recruited for the study were divided into cases with seropositivity for Neisseria gonorrhoeae (gonococcal antibody test), Chlamydia trachomatis (enzyme immunoassay) or Treponema pallidum (Treponema pallidum haemagglutination assay) (n= 26) and controls without antibodies to these species (n= 196). Socio-demographic data were obtained and physical examination including genital examination was performed in order to classify the form of FGM. Cases and controls were compared using logistic regression to adjust for covariates. Extent of FGM and seropositivity for C. trachomatis, N. gonorrhoeae or T. pallidum. Of the cases, 85% had undergone the most severe form of FGM involving labia majora compared with 78% of controls (n.s.). Thus, there was no association between serological evidence of STIs and extent of FGM. The only factor that differed significantly between the groups was the education level, cases with STIs having significantly shorter education (P= 0.03) than controls. There is a little difference between cases and controls in regard to FGM. Having in mind the relatively small sample size, the results still indicate that FGM seems neither to be a risk factor for nor protective against acquiring STIs. This is important as argument against traditional beliefs that FGM protects against pre/extramarital sex.
    BJOG An International Journal of Obstetrics & Gynaecology 05/2006; 113(4):469-74. DOI:10.1111/j.1471-0528.2006.00896.x · 3.86 Impact Factor


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