Effects of large doses of calciferol on patients with rheumatoid arthritis. A double-blind clinical trial.

Scandinavian Journal of Rheumatology (Impact Factor: 2.22). 02/1973; 2(4):173-6.
Source: PubMed

ABSTRACT In a double-blind clinical trial on 49 patients with rheumatoid arthritis, calciferol was given in a dose of 100 000 IU per day for 1 year to 24 patients, while the remaining 25 received placebo. Objective and subjective improvement was noted in 67% of the calciferol group and in 36% of the control group, while objective and subjective deterioration was noted in 4% of the calciferol group and in 32% of the control group. The mean values for sedimentation rate and a2-globulin decreased and the mean hemoglobin level increased in the calciferol group. The consumption of analgesics and antiinflammatory medicines decreased significantly in the calciferol group and after 1 year morning stiffness had eased and hand strength had increased in this group.

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    ABSTRACT: Significant controversy has emerged over the last decade concerning the effects of vitamin D on skeletal and nonskeletal tissues. The demonstration that the vitamin D receptor is expressed in virtually all cells of the body and the growing body of observational data supporting a relationship of serum 25-hydroxyvitamin D to chronic metabolic, cardiovascular, and neoplastic diseases have led to widespread utilization of vitamin D supplementation for the prevention and treatment of numerous disorders. In this paper, we review both the basic and clinical aspects of vitamin D in relation to nonskeletal organ systems. We begin by focusing on the molecular aspects of vitamin D, primarily by examining the structure and function of the vitamin D receptor. This is followed by a systematic review according to tissue type of the inherent biological plausibility, the strength of the observational data, and the levels of evidence that support or refute an association between vitamin D levels or supplementation and maternal/child health as well as various disease states. Although observational studies support a strong case for an association between vitamin D and musculoskeletal, cardiovascular, neoplastic, and metabolic disorders, there remains a paucity of large-scale and long-term randomized clinical trials. Thus, at this time, more studies are needed to definitively conclude that vitamin D can offer preventive and therapeutic benefits across a wide range of physiological states and chronic nonskeletal disorders.
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