[Show abstract][Hide abstract] ABSTRACT: A gnotobiotic isolation system based on those developed in veterinary research has been constructed for hospital use. Fifteen patients with leukaemia and neutropenia spent a total of 110 weeks in plastic isolators, and none acquired any infection. Endogenous flora was effectively suppressed by topical antiseptics and gastrointestinal decontamination effected with nonabsorbable antibiotics. The isolator system was acceptable to patients and staff and much cheaper than the use of sterile rooms. Other advantages of the system are portability, easy storage, and use on ordinary open wards without prejudice to the microbiological protection afforded. It is as yet uncertain whether protective environments of this type will substantially improve the outcome of treatment for the acute leukaemias.
British medical journal 01/1976; 4(5996):549-52. DOI:10.1136/bmj.4.5996.549
[Show abstract][Hide abstract] ABSTRACT: Over the last 5 years plastic isolators have been used for the prevention of infection in patients with severe neutropenia. Fifteen patients in differing stages of acute myeloid and chronic granulocytic leukaemia were managed in isolators for a total of 110 patient-weeks. The mean duration of isolation for each patient was 7·4 weeks with a range of 2-14 weeks. There was no evidence that any of the isolated patients acquired infection with any exogenous micro-organism. The psychological problems of isolation proved less onerous for the patients than had been anticipated by the medical and nursing staff and no patient had to be removed from isolation for psychiatric reasons. Unfortunately the reduced incidence of clinical infection in the isolated patients was not obviously associated with an increase in effectiveness of their anti-leukaemic treatment.
Postgraduate Medical Journal 10/1976; 52(611):558-92. DOI:10.1136/pgmj.52.611.558 · 1.55 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: The therapeutic method of reverse isolation in patients using an aseptic environment in the Life Island or Laminar Air Flow Unit apparatus systems is described on the basis of data from the literature and the authors' experience. A historical summary of views on treatment in an aseptic environment is followed by a description of the method of work with the system of reverse isolation, including important technical, operational and other data. The main indications for treatment are given and the authors' experience with the reverse isolation of 36 patients suffering from blood diseases who were treated in this way over the past four years is evaluated. The experience gained confirms data from the literature that reverse isolation is unequivocally successful in reducing the number of infections in immunologically weakened persons. Other aspects have not yet been definitely assessed.
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