Fluorescein angiography of the fundus in diabetic retinopathy.

British Medical Bulletin (Impact Factor: 3.95). 06/1970; 26(2):166-70.
Source: PubMed
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    Diabetes Care 03/1978; 1(2):127-37. DOI:10.2337/diacare.1.2.127 · 8.57 Impact Factor
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    ABSTRACT: The contractile protein actin was identified within retinal capillary pericytes and endothelial cells. In capillary cross-sections, circumferential pericyte processes showed numerous parallel bundles of actin filaments forming a cap over the adjacent endothelial cells. The latter contained few actin filaments but a considerable number of intermediate filaments. Pericytes and endothelial cells communicated via gaps in the adluminal basal lamina. These special anatomic relationships are interpreted as evidence for a contractile role of retinal capillary pericytes and against a contractile role of retinal capillary endothelial cells
    Investigative Ophthalmology &amp Visual Science 01/1981; 19(12):1433-41. · 3.66 Impact Factor
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    ABSTRACT: Fluorescein angiograms were performed to evaluate perifoveal capillary blood velocities (v), capillary density (perifoveal intercapillary areas: PIA) and the foveal avascular zone (FAZ) by means of the scanning laser technique (SLO-101 Rodenstock). The angiograms were digitally stored and the data quantified off-line with an image analyzing system (IBAS). In the present study 46 patients with non-insulin-dependent diabetes mellitus (NIDDM) were examined and their data compared with that of 31 healthy volunteers. The perifoveal capillary flow velocity of the NIDDM subjects (v = 2.330.36 mm/s) was significantly (P v = 2.86 0.41 mm/s). The perifoveal intercapillary areas in the foveal avascular zone were significantly increased in patients with NIDDM (PIA=10029 3402 m2; FAZ = 0.415 0.272 mm2) as compared with healthy subjects (PIA = 3965 467 m2; FAZ=0.221 0.071 mm2). These data suggest the possibility that a decrease in perifoveal capillary blood velocities in combination with decreased capillary density (enlarged PIA) and an enlargement of the foveal avascular zone may occur in patients with NIDDM. The determination of these parameters could help in monitoring the progress of diabetic retinopathy and diabetic maculopathy.
    Albrecht von Graæes Archiv für Ophthalmologie 01/1994; 232(4):225-231. DOI:10.1007/BF00184010 · 2.33 Impact Factor