Article

Cytogenetic survey of XYY males in two juvenile court populations, with a case report.

Journal of Medical Genetics (Impact Factor: 5.7). 10/1972; 9(3):287-8. DOI: 10.1136/jmg.9.3.287
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    The American Journal of Human Genetics 08/1974; 26(4):504-11. · 11.20 Impact Factor
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    ABSTRACT: This paper reports the testicular size and shape of 12 men with 47,XYY, 14 men with 47,XXY, and 52 matched controls with 46,XY. The abnormal karyotypes were identified in a systematic population search for XYY and XXY men. The subjects and their matched controls were examined in a double-blind fashion. The testes of the XYY men showed no significant differences from those of their XY controls for volume or shape. This indicates that previous reports of abnormal testes in XYYs reflect selection and publication bias and do not provide an accurate description of the condition of 47,XYY men's testicles. As expected, the testes of the XXY men were significantly smaller than those of their XY controls, and there was also a difference in shape. However, the mean size in this sample of XXYs was larger than in previous reports on Klinefelter syndrome patients, indicating that previous reports on XXYs, identified in clinics for male hypogonadism and other institutions, also suffered from selection bias.
    The American Journal of Human Genetics 12/1979; 31(6):697-703. · 11.20 Impact Factor
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    ABSTRACT: Consecutive X and Y chromatin survey among 1,581 Japanese juvenile delinquents had been undertaken for three years. Among 1,371 males, five 47,XYY males and four 47,XXY males were found (0.36% and 0.29% respectively), while no numerical abnormalities of X chromatin were found in 210 females. Frequency of 47,XYY males in the present study is significantly higher than that of newborns. With respect to sample size, for which the frequencies of 47,XYY and 47,XXY males have been estimated, a possible bias in the studies reported previously was suggested.
    The Japanese Journal of Human Genetics 04/1979; 24(1):21-5.

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