Article

The absorption of p-toluenediamine through human skin in hair dyeing.

Institute of Pharmacology, University of Munich, Munich, Germany
Toxicology and Applied Pharmacology (Impact Factor: 3.63). 12/1968; 13(3):325-31. DOI: 10.1016/0041-008X(68)90106-3
Source: PubMed

ABSTRACT After the hair of 5 persons had been dyed with a simple dye, prepared by oxidizing a mixture of 2.5 g of p-toluenediamine sulfate and 2.5 g resorcinol with hydrogen peroxide, an average of 3.7 mg N,N′-diacetyl-p-toluenediamine appeared in the urine. A similar amount of N,N′-diacetyl-p-toluenediamine, namely 4.5 mg, was found in the urine when 5.5 mg of p-toluenediamine was subcutaneously injected. From these data it is calculated that about 4.6 mg of p-toluenediamine was either absorbed during the hair dyeing or produced in vivo from a compound formed during the preparation of the hair dye and absorbed through the skin while the dye was applied to the hair and scalp.

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