Changes of [3H]spiroperidol binding in the renal artery of aged rabbits

Dipartimento di Scienze Neurologiche-Univesità “La Sapienza”, Via A. Borelli 50, 00161 Roma Italy
Mechanisms of Ageing and Development (Impact Factor: 3.4). 12/1984; 28(1):41-5. DOI: 10.1016/0047-6374(84)90151-9
Source: PubMed


Using mature (12 months), old (70 months) rabbits and 3H-labeled spiroperidol, the characteristics of renal artery dopamine receptors were studied. In old age the dissociation constant of [3H]spiroperidol was unchanged, while maximum specific binding was reduced more than 45%. The present data seem to indicate an impairment of peripheral dopaminergic function in ageing.

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