The authors report the results of a large-scale double-blind study comparing the anxiolytic effects of alprazolam, a triazolobenzodiazepine; diazepam, a 1,4-benzodiazepine; and placebo in 151 anxious outpatients. Alprazolam and diazepam produced similar clinical improvement, which was significantly larger than improvement produced by placebo and was clearly evident after only 1 week of treatment. The incidence of sedation was lower with alprazolam than with diazepam.
"diatric GAD ( known then as anxiety neurosis ) ; benzodiazepines soon replaced them because they are safer , especially in case of overdose . Benzodiazepines bind to the gaba - aminobutyric acid membrane receptor ( GABA ) that causes inhibition of the nervous system . While there is much data documenting the efficacy of benzodiazepines in adults ( Rickels et al . 1983 , 1990 ) , for whom benzodiazepines are sometimes used to treat acute GAD , this is not the case with children and adolescents . With respect to benzodiazepines , the pediatric data are unclear and consist of the results of small , open - label , nonrandomized trials ( Bernstein et al . 1990 ; Graae et al . 1994 ; Simeon et al . 1992 ) "
[Show abstract][Hide abstract] ABSTRACT: Pediatric anxiety is a prevalent psychiatric disorder that may have important implications for school, social, and academic function. Psychopharmacological approaches to the treatment of pediatric anxiety have expanded over the past 20 years and increasing empirical evidence helps guide current clinical practice.
To review studies which examine the pharmacological treatment of pediatric anxiety disorders, including obsessive-compulsive disorder and to summarize treatment implications.
All relevant studies were searched using MEDLINE and PsycINFO search engines, supplemented by a manual bibliographical search; studies published between 1985 and 2006 that met inclusion criteria were examined.
This article provides a systematic review of the psychopharmacological treatment of pediatric anxiety disorders based on available empirical evidence, with a focus on randomized controlled trials. General treatment principles and pharmacological management of specific pediatric anxiety disorders are also reviewed.
There is good evidence to support the efficacy of several pharmacological agents including the selective serotonin reuptake inhibitors to treat pediatric anxiety and obsessive-compulsive disorder, although there are still many unanswered questions.
"Of these, some found alprazolam and diazepam to be of comparable efficacy (Aden & Thein, 1980; Davison et al., 1983; Rickels et al., 1983) whereas two reported that alprazolam was superior to diazepam (Cohn, 1981; Maletzky, 1980). All five studies demonstrated both drugs to be superior to placebo. "
[Show abstract][Hide abstract] ABSTRACT: The clinical efficacy of alprazolam has been evaluated in both anxiety states and depressive disorders. In anxiety neurosis, studies have been conducted vs placebo and/or other benzodiazepine tranquilizers. Reports, to date, with regard to panic/phobia disorders have been limited to open-label studies and a single report from a placebo-controlled study. In depression, both open-label and double-blind studies (vs tricyclic antidepressants) have been published.
British Journal of Clinical Pharmacology 02/1985; 19 Suppl 1:57S-59S. DOI:10.1111/j.1365-2125.1985.tb02743.x · 3.88 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Alprazolam is a recently marketed triazolobenzodiazepine. The animal pharmacological data reviewed here suggest a potent anxiolytic action. But, in addition, an antidepressant activity was revealed in clinical studies and subsequently studied in animal assays. As an extension of these activities, alprazolam also displays efficacy in panic and phobic disorders. Data relating to a wide range of pharmacological activities and pharmacokinetics of alprazolam are also reviewed.
Drug Development Research 01/1985; 6(1):1 - 12. DOI:10.1002/ddr.430060102 · 0.77 Impact Factor
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